Evidence map›Paper›PMID 34743750›Full record

ArticleJournal of hematology & oncology2021

N6-methyladenosine reader IMP2 stabilizes the ZFAS1/OLA1 axis and activates the Warburg effect: implication in colorectal cancer.

Senxu Lu, Li Han, Xiaoyun Hu, Tong Sun, Dongping Xu, Yalun Li, Qiuchen Chen, Weifan Yao, Miao He, Zhenning Wang and 2 more

Open access · goldAbstract read
In one paragraph

Article in Journal of hematology & oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed
8.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 119 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Crosstalk between mFrontiers in immunology · 2026
    Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. The Role of N6-Methyladenosine in Mitochondrial Dysfunction and Pathology.International journal of molecular sciences · 2025
    Review
  15. Abnormal changes in metabolites caused by mJournal of advanced research · 2025
    Review
  16. Article
  17. IMPlications of IMP2 in RNA Biology and Disease.International journal of molecular sciences · 2025
    Review
  18. Article
  19. Review
  20. Up-regulation of mBMC cancer · 2025
    Article

18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Senxu Lu *Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, 110122, People's Republic of China.
Li Han *Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, 110122, People's Republic of China.
Xiaoyun HuDepartment of Pharmacology, School of Pharmacy, China Medical University, Shenyang, 110122, People's Republic of China.
Tong SunDepartment of Pharmacology, School of Pharmacy, China Medical University, Shenyang, 110122, People's Republic of China.
Dongping XuDepartment of Pharmacology, School of Pharmacy, China Medical University, Shenyang, 110122, People's Republic of China.
Yalun LiDepartment of Anorectal Surgery, First Affiliated Hospital of China Medical University, Shenyang, 110001, People's Republic of China.
Qiuchen ChenDepartment of Pharmacology, School of Pharmacy, China Medical University, Shenyang, 110122, People's Republic of China.
Weifan YaoDepartment of Pharmacology, School of Pharmacy, China Medical University, Shenyang, 110122, People's Republic of China.
Miao HeDepartment of Pharmacology, School of Pharmacy, China Medical University, Shenyang, 110122, People's Republic of China.
Zhenning WangDepartment of Surgical Oncology and General Surgery, Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors, Ministry of Education, First Affiliated Hospital of China Medical University, Shenyang, 110001, People's Republic of China. znwang@cmu.edu.cn.
Huizhe WuDepartment of Pharmacology, School of Pharmacy, China Medical University, Shenyang, 110122, People's Republic of China. wuhz@cmu.edu.cn.
Minjie WeiDepartment of Pharmacology, School of Pharmacy, China Medical University, Shenyang, 110122, People's Republic of China. minjieweicmu@163.com.ORCID 0000-0002-5744-1603
Ministry of Education · KNShenyang Medical College · CNFirst Hospital of China Medical University · CNTarget (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAccumulating evidence shows that N6-methyladenine (m

methodsThe relationship between candidate lncRNA and m

resultsWe identified that the crosstalk of the m

conclusionsOur findings reveal a new cancer-promoting mechanism, that is, the critical modulation network underlying m

Indexed as

AdenosineAdenosine TriphosphatasesCell Line, TumorColorectal NeoplasmsGene Expression Regulation, NeoplasticGTP-Binding ProteinsHT29 CellsHumansRNA-Binding ProteinsRNA, Long NoncodingWarburg Effect, OncologicAdenosineAdenosine TriphosphatasesGTP-Binding ProteinsIGF2BP2 protein, humanN-methyladenosineOLA1 protein, humanRNA-Binding ProteinsRNA, Long NoncodingZFAS1 long non-coding RNA, humanATP-hydrolyzing and glycolysisColorectal cancerIMP2m6A methylationOLA1ZFAS1

Identifiers

PMID34743750
PMCPMC8574039
OpenAlexW3214511150

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.