Evidence map›Paper›PMID 34743689›Full record

ArticleBMC ophthalmology2021

Causes of poor eye contact in infants: a population-based study.

Mette Levinsen, Malene Landbo Børresen, Laura Roos, Karen Grønskov, Line Kessel

Open access · goldAbstract read
In one paragraph

Article in BMC ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Visual function and autism spectrum disorder.Journal of neural transmission (Vienna, Austria : 1996) · 2026
    Review
  2. Visual Function Characteristics inJournal of clinical medicine · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Mette LevinsenDepartment of Ophthalmology, Rigshospitalet, Valdemar Hansens Vej 13, 2600, Glostrup, Denmark. mettelevinsen@gmail.com.
Malene Landbo BørresenDepartment of Pediatrics and Adolescent Medicine, Rigshospitalet, Copenhagen, Denmark.
Laura RoosDepartment of Clinical Genetics, Rigshospitalet, Copenhagen, Denmark.
Karen GrønskovDepartment of Clinical Genetics, Rigshospitalet, Copenhagen, Denmark.
Line KesselDepartment of Ophthalmology, Rigshospitalet, Valdemar Hansens Vej 13, 2600, Glostrup, Denmark.
Rigshospitalet · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEstablishing eye contact between infants and parents is important for early parent-child bonding and lack of eye contact may be a sign of severe underlying disease. The aim of the study was to evaluate the causes of poor or lacking eye contact in infants.

methodsCross-sectional study reviewing all referrals of infants ≤1 year of age from January 1rst, 2016 to December 31rst, 2018. Medical information was retrieved from patient files covering pregnancy, birth, diagnostic work-up and ocular parameters such as refraction, visual acuity and structural findings.

resultsWe identified 99 infants with poor or lacking eye contact. The relative frequency of causes was neurologic disease 36.4% (36/99), delayed visual maturation 24.2% (24/99), ocular disease 21.2% (21/99) and idiopathic infantile nystagmus 4.0% (4/99). Fourteen infants had a visual function within age-related norms at first examination despite poor eye contact at the time of referral. Of the infants with available data, 18/27 (33.3%) with neurologic cause, 15/23 (65.2%) with delayed visual maturation and 9/21 (42.9%) with ocular cause had visual acuity within the age-related norm at latest follow-up (0-41 months). In 23 infants, a genetic cause was found.

conclusionPoor eye contact in infants may be a sign of severe underlying disease, such as neurological or ocular disease. Close collaboration between pediatric ophthalmologists and neuro-pediatricians are warranted in the management of these infants.

Indexed as

Genetic Diseases, X-LinkedNystagmus, CongenitalChildChild, PreschoolCross-Sectional StudiesFollow-Up StudiesHumansInfantInfant, NewbornVisual AcuityDelayed visual maturationInfantInfantsNystagmusPoor eye contactVision

Identifiers

PMID34743689
PMCPMC8572507
OpenAlexW3212507589

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.