Evidence map›Paper›PMID 34743687›Full record

ArticleBMC public health2021

The rural Uganda non-communicable disease (RUNCD) study: prevalence and risk factors of self-reported NCDs from a cross sectional survey.

Trishul Siddharthan, Robert Kalyesubula, Brooks Morgan, Theresa Ermer, Tracy L Rabin, Alex Kayongo, Richard Munana, Nora Anton, Katharina Kast, Elke Schaeffner and 3 more

Abstract read
In one paragraph

Article in BMC public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Trishul Siddharthan *Division of Pulmonary and Critical Care, School of Medicine, University of Miami, 1951 NW 7th Ave, Suite 2308, Miami, FL, 33136, USA. tsiddhar@miami.edu.ORCID 0000-0001-9914-1839
Robert Kalyesubula *Makerere College of Health Sciences, Makerere University, Kampala, Uganda.
Brooks MorganDivision of Pulmonary and Critical Care, School of Medicine, University of Miami, 1951 NW 7th Ave, Suite 2308, Miami, FL, 33136, USA.
Theresa ErmerFaculty of Medicine, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Tracy L RabinDepartment of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
Alex KayongoMakerere College of Health Sciences, Makerere University, Kampala, Uganda.
Richard MunanaMakerere College of Health Sciences, Makerere University, Kampala, Uganda.
Nora AntonWorld Health Summit c/o Charité Universitätsmedizin Berlin, Berlin, Germany.
Katharina KastDepartment of Nephrology and Medical Intensive Care, Charité Universitätsmedizin Berlin, Berlin, Germany.
Elke SchaeffnerInstitute of Public Health, Charité Universitätsmedizin Berlin, Berlin, Germany.
Bruce KirengaMakerere College of Health Sciences, Makerere University, Kampala, Uganda.
Felix KnaufDepartment of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
Rural Uganda Non Communicable Disease Study Investigators

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

backgroundNon-communicable diseases (NCDs) are an increasing global concern, with morbidity and mortality largely occurring in low- and middle-income settings. We established the prospective Rural Uganda Non-Communicable Disease (RUNCD) cohort to longitudinally characterize the NCD prevalence, progression, and complications in rural Africa.

methodsWe conducted a population-based census for NCD research. We systematically enrolled adults in each household among three sub-counties of the larger Nakaseke Health district and collected baseline demographic, health status, and self-reported chronic disease information. We present our data on self-reported chronic disease, as stratified by age, sex, educational attainment, and sub-county.

resultsA total of 16,694 adults were surveyed with 10,563 (63%) respondents enrolled in the self-reported study. Average age was 37.8 years (SD = 16.5) and 45% (7481) were male. Among self-reported diseases, hypertension (HTN) was most prevalent (6.3%). 1.1% of participants reported a diagnosis of diabetes, 1.1% asthma, 0.7% COPD, and 0.4% kidney disease. 2.4% of the population described more than one NCD. Self-reported HTN was significantly higher in the peri-urban subcounty than in the other two rural sub-counties (p < 0.001); diagnoses for all other diseases did not differ significantly between sub-counties. Odds for self-reported HTN increased significantly with age (OR = 1.87 per 10 years of age, 95% CI 1.78-1.96). Male sex was associated with lower odds of reporting asthma (OR = 0.53, 95% CI 0.34-0.82) or HTN (OR = 0.31, 95% CI 0.26-0.40).

conclusionsThe RUNCD will establish one of the largest NCD patient cohorts in rural Africa. First analysis highlights the feasibility of systematically enrolling large numbers of adults living in a rural Ugandan district. In addition, our study demonstrates low levels of self-reported NCDs compared to the nation-wide established levels, emphasizing the need to better educate, characterize, and care for the majority of rural communities.

Indexed as

Noncommunicable DiseasesAdultChildCross-Sectional StudiesHumansMalePrevalenceProspective StudiesRisk FactorsRural PopulationSelf ReportUgandaLow- and middle-income countriesNon-communicable diseasesRural

Identifiers

PMID34743687
PMCPMC8572568

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.