ArticlePhilosophical transactions. Series A, Mathematical, physical, and engineering sciences2021
Systems for intricate patterning of the vertebrate anatomy.
Article in Philosophical transactions. Series A, Mathematical, physical, and engineering sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed.
- Characterisation of human hair follicle development.Journal of anatomy · 2026Article
- Genetic dissection of leg and back feather follicle density in yellow-feathered broiler: integrative GWAS and transcriptome analysis reveal the regulatory role of SERPINF1.Poultry science · 2026Article
- Chemotactic self-organization captures the dynamics of mammalian hair follicle patterning.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Fast Numerical Solvers for Parameter Identification Problems in Mathematical Biology.Journal of scientific computing · 2026Article
- Designing reaction-cross-diffusion systems with Turing and wave instabilities.Journal of mathematical biology · 2025Article
- Article
- Radially patterned morphogenesis of murine hair follicle placodes ensures robust epithelial budding.Developmental cell · 2024Article
- How a reaction-diffusion signal can control spinal cord regeneration in axolotls: A modeling study.iScience · 2024Article
- Unraveling biochemical spatial patterns: Machine learning approaches to the inverse problem of stationary Turing patterns.iScience · 2024Article
- Review
- Periodic pattern formation during embryonic development.Biochemical Society transactions · 2024Review
- Novel Aspects in Pattern Formation Arise from Coupling Turing Reaction-Diffusion and Chemotaxis.Bulletin of mathematical biology · 2023Article
- An active traveling wave of Eda/NF-κB signaling controls the timing and hexagonal pattern of skin appendages in zebrafish.Development (Cambridge, England) · 2023Article
- An active traveling wave of Eda/NF-kB signaling controls the timing and hexagonal pattern of skin appendages in zebrafish.bioRxiv : the preprint server for biology · 2023Article
- Closing the loop on morphogenesis: a mathematical model of morphogenesis by closed-loop reaction-diffusion.Frontiers in cell and developmental biology · 2023Article
- Modeling of ionizing radiation induced hair follicle regenerative dynamics.Journal of theoretical biology · 2022Article
- Patterning, From Conifers to Consciousness: Turing's Theory and Order From Fluctuations.Frontiers in cell and developmental biology · 2022Review
- Introduction to 'Recent progress and open frontiers in Turing's theory of morphogenesis'.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2021Article
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3 authors.
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Abstract
Periodic patterns form intricate arrays in the vertebrate anatomy, notably the hair and feather follicles of the skin, but also internally the villi of the gut and the many branches of the lung, kidney, mammary and salivary glands. These tissues are composite structures, being composed of adjoined epithelium and mesenchyme, and the patterns that arise within them require interaction between these two tissue layers. In embryonic development, cells change both their distribution and state in a periodic manner, defining the size and relative positions of these specialized structures. Their placement is determined by simple spacing mechanisms, with substantial evidence pointing to a variety of local enhancement/lateral inhibition systems underlying the breaking of symmetry. The nature of the cellular processes involved, however, has been less clear. While much attention has focused on intercellular soluble signals, such as protein growth factors, experimental evidence has grown for contributions of cell movement or mechanical forces to symmetry breaking. In the mesenchyme, unlike the epithelium, cells may move freely and can self-organize into aggregates by chemotaxis, or through generation and response to mechanical strain on their surrounding matrix. Different modes of self-organization may coexist, either coordinated into a single system or with hierarchical relationships. Consideration of a broad range of distinct biological processes is required to advance understanding of biological pattern formation. This article is part of the theme issue 'Recent progress and open frontiers in Turing's theory of morphogenesis'.
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