ArticleStroke2022
Clonal Hematopoiesis Is Associated With Higher Risk of Stroke.
Erratum issuedOpen access · bronzeAbstract read
In one paragraph
Article in Stroke, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 137 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
137citing papers in PubMed, 3 pooled it
19.3field-weighted citation impact, top 1% of its field
What it found
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The trial behind it
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Who cites it
137 citing papers in PubMed, 3 syntheses or guidelines pooled it, 194 citations in OpenAlex.
- Clinical impact of clonal hematopoiesis on patients with solid tumors: a systematic review and meta-analysis.Frontiers in oncology · 2026Pooled it
- Association of clonal haematopoiesis with heart failure incidence and outcomes: A systematic review and meta-analysis.European journal of heart failure · 2025Pooled it
- Clonal hematopoiesis of indeterminate potential as a prognostic factor: a systematic review and meta-analysis.Blood advances · 2024Pooled it
- Clonal Hematopoiesis and Clinical Outcomes in Metastatic Castration-Resistant Prostate Cancer Patients Given Androgen Receptor Pathway Inhibitors (Alliance A031201).Clinical cancer research : an official journal of the American Association for Cancer Research · 2024Trial
- Mutations in CHIP-associated genes at myeloid neoplasm diagnosis and risk of cardiovascular/cerebrovascular events.Annals of medicine · 2026Article
- Clonal hematopoiesis of indeterminate potential (CHIP), vascular somatic mutation, and cardiovascular disease: A narrative review.Vascular medicine (London, England) · 2026Review
- Genetic evidence supports the combined targeting of lipoprotein(a) and LDL cholesterol to reduce coronary artery disease risk.Nature cardiovascular research · 2026Article
- Clonal hematopoietic mutations as a predictor of adverse outcomes in cytopenic patients with chronic kidney disease.Blood research · 2026Article
- Cerebral small vessel disease: pearls and pitfalls from unexplored risk factors to treatment.Arquivos de neuro-psiquiatria · 2026Review
- Clonal Hematopoiesis and Type 2 Diabetes: A Narrative Review.Journal of diabetes · 2026Review
- Clonal hematopoiesis of indeterminate potential (CHIP)-a pivotal contributor of aging and related disorders.Annals of translational medicine · 2026Review
- A paradigm shift in the treatment of patients with polycythemia vera. The initial early use of recombinant interferon-alpha.Leukemia · 2026Review
- Association Between Clonal Hematopoiesis and Cardiometabolic Disease: A Systematic Review and Meta-Analysis.JACC. CardioOncology · 2026Article
- Clonal Hematopoiesis and Risk of Stroke: Evidence From Over 800 000 Individuals Across 3 Cohorts.Stroke · 2026Article
- Clonal haematopoiesis and cardiovascular disease, defining risk, filling gaps, and framing the future.NPJ cardiovascular health · 2026Review
- Metabolic polygenic risk scores for prediction of obesity, type 2 diabetes, and related morbidities.Cell metabolism · 2026Article
- Clonal hematopoiesis and thrombosis risk-what are research and clinical gaps?Research and practice in thrombosis and haemostasis · 2026Review
- Clonal Hematopoiesis of Indeterminate Potential (CHIP): A Model of Mutation-Driven Thromboinflammation.Cancers · 2026Review
- Clonal hematopoiesis is associated with future diseases and mortality.Chinese medical journal · 2026Article
- Geroscience insights into difficult-to-treat rheumatoid arthritis: the role of unhealthy aging, comorbidity, and therapeutic complexity.GeroScience · 2026Review
77 more citing papers are in PubMed but not listed here.
Corrections and comments
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- Erratum issued
Authors and funding
33 authors at 20 institutions in 3 countries.
Romit Bhattacharya *Cardiovascular Research Center, Massachusetts General Hospital, Boston (R.B., S.M.Z., M.M.U., P.N.).ORCID 0000-0002-0782-4753
Seyedeh M Zekavat *Cardiovascular Research Center, Massachusetts General Hospital, Boston (R.B., S.M.Z., M.M.U., P.N.).ORCID 0000-0003-4026-8944
Jeffrey HaesslerDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA (J.H., C.K.).
Myriam FornageBrown Foundation Institute of Molecular Medicine, McGovern Medical School (M.F.), The University of Texas Health Science Center at Houston.ORCID 0000-0003-0677-8158
Laura RaffieldDepartment of Genetics (L.R.), University of North Carolina at Chapel Hill.ORCID 0000-0002-7892-193X
Md Mesbah UddinCardiovascular Research Center, Massachusetts General Hospital, Boston (R.B., S.M.Z., M.M.U., P.N.).ORCID 0000-0003-1846-0411
Alexander G BickDivision of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (A.G.B.).ORCID 0000-0001-5824-9595
Abhishek NiroulaProgram in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, MA (R.B., S.M.Z., M.M.U., A.N., P.N.).ORCID 0000-0002-5904-0635
Bing YuHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health (M.F., B.Y., A.C.M.), The University of Texas Health Science Center at Houston.ORCID 0000-0003-4818-1077
Christopher GibsonDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA (A.N., C.G., B.L.E.).ORCID 0000-0002-3700-5310
Gabriel GriffinDepartment of Pathology, Brigham and Women's Hospital, Boston, MA (G.G.).
Alanna C MorrisonCardiovascular Research Center, Massachusetts General Hospital, Boston (R.B., S.M.Z., M.M.U., P.N.).ORCID 0000-0001-6381-4296
Bruce M PsatyCardiovascular Health Research Unit, Department of Medicine (B.M.P.), University of Washington, Seattle.ORCID 0000-0002-7278-2190
William T LongstrethDepartment of Neurology (W.T.L.), University of Washington, Seattle.
Joshua C BisCardiovascular Health Research Unit, Department of Medicine (J.C.B.), University of Washington, Seattle.ORCID 0000-0002-3409-1110
Stephen S RichCenter for Public Health Genomics, University of Virginia, Charlottesville (S.S.R.).ORCID 0000-0003-3872-7793
Jerome I RotterDepartment of Pediatrics, Institute for Translational Genomics and Population Sciences, The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA (J.I.R.).ORCID 0000-0001-7191-1723
Russell P TracyDepartment of Pathology and Laboratory Medicine, University of Vermont College of Medicine, Burlington (R.P.T.).
Adolfo CorreaThe Jackson Heart Study, University of Mississippi Medical Center (A.C.).ORCID 0000-0002-9501-600X
Sudha SeshadriGlenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio (S.S.).
Andrew JohnsonBoston University and the NHLBI's Framingham Heart Study, MA (S.S., A.J.).ORCID 0000-0001-6369-5178
Jason M CollinsDepartment of Epidemiology, Gillings School of Global Public Health (J.M.C.), University of North Carolina at Chapel Hill.ORCID 0000-0002-2903-797X
Kathleen M HaydenDepartment of Social Sciences and Health Policy, Wake Forest School of Medicine, Winston-Salem, NC (K.M.H.).ORCID 0000-0002-7745-3513
Tracy E MadsenDepartments of Emergency Medicine (T.E.M.), Brown University, Providence, RI.ORCID 0000-0001-5101-0776
Christie M BallantyneDepartment of Medicine, Baylor College of Medicine, Houston, TX (C.M.B.).ORCID 0000-0002-6432-1730
Siddhartha JaiswalDepartment of Pathology, University School of Medicine, CA (S.J.).ORCID 0000-0002-9597-0477
Benjamin L EbertDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA (A.N., C.G., B.L.E.).ORCID 0000-0003-0197-5451
Charles KooperbergDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA (J.H., C.K.).ORCID 0000-0002-7986-8560
JoAnn E MansonDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (J.E.M.).ORCID 0000-0002-9426-7595
Eric A WhitselDepartment of Medicine, School of Medicine (E.A.W.), University of North Carolina at Chapel Hill.ORCID 0000-0003-4843-3641
NHLBI Trans-Omics for Precision Medicine Program
Pradeep NatarajanCardiovascular Research Center, Massachusetts General Hospital, Boston (R.B., S.M.Z., M.M.U., P.N.).ORCID 0000-0001-8402-7435
Alexander P ReinerDepartment of Epidemiology (A.P.R.), University of Washington, Seattle.ORCID 0000-0002-1427-4470
Broad Institute · USUniversity of Washington · USUniversity of North Carolina at Chapel Hill · USCape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa · ZABaylor College of Medicine · USBoston University · USBrigham and Women's Hospital · USBrown Foundation · USBrown University · USDana-Farber Cancer Institute · USFramingham Heart Study · USHoward Hughes Medical Institute · USMassachusetts General Hospital · USStanford University · USThe University of Texas Health Science Center at Houston · USUCLA Medical Center · USUniversity of Mississippi Medical Center · USUniversity of Vermont · USUniversity of Virginia · USVanderbilt University Medical Center · US
Funding
Large Scale Sequencing and Analysis of GenomesU54HG003067 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIEL, STACEY, LANDER, ERIC S · 2004 to 2015
$568.6MThe Human Genome Sequencing CenterU54HG003273 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI GIBBS, RICHARD A · 2004 to 2015
$341.3MUCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1MGenomic Architecture of Common Disease in Diverse Populations: WGS of Ongoing Hemorrhagic Stroke Study SupplementUM1HG008898 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI GIBBS, RICHARD A · 2016 to 2020
$77.0MInstitute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1MWOMEN'S HEALTH INITIATIVE - CLINICAL COORDINATING CENTER: TASK AREA B - LONG LIFE STUDY VISIT 2 LIMITED HOME VISIT75N92021D00001 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI ANDERSON, GARNET L. · 2021 to 2025
$52.0MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4MUNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3MSubclinical Vascular Contributions to Alzheimer's Disease: The Multi-Ethnic Study of Atherosclerosis (MESA) Multisite Study of AD (Renewal)R01AG058969 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Timothy M. Hughes, YONGMEI LIU · 2018 to 2026
$33.4MWake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3MFRAMINGHAM HEART STUDY - YEAR 5 EXAM75N92019D00031 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · 2019 to 2024
$29.8MBuilding on GWAS for NHLBI-disease: the CHARGE consortiumRC2HL102419 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BOERWINKLE, ERIC A. · 2009 to 2010
$27.6MNCATS NIH HHS KL2 TR002490NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001420NCATS NIH HHS UL1 TR001881NCCIH NIH HHS R01 AT011729NHGRI NIH HHS U54 HG003067NHGRI NIH HHS U54 HG003273NHGRI NIH HHS UM1 HG008898NHLBI NIH HHS 75N92019D00031NHLBI NIH HHS 75N92020D00001NHLBI NIH HHS 75N92020D00002NHLBI NIH HHS 75N92020D00003NHLBI NIH HHS 75N92020D00004NHLBI NIH HHS 75N92020D00005NHLBI NIH HHS 75N92020D00006NHLBI NIH HHS 75N92020D00007NHLBI NIH HHS 75N92021D00001NHLBI NIH HHS 75N92021D00002NHLBI NIH HHS 75N92021D00006NHLBI NIH HHS DP2 HL157540NHLBI NIH HHS F30 HL149180NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268201100001INHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HHSN268201500003CNHLBI NIH HHS HHSN268201500003INHLBI NIH HHS HHSN268201700001CNHLBI NIH HHS HHSN268201700001INHLBI NIH HHS HHSN268201700002CNHLBI NIH HHS HHSN268201700002INHLBI NIH HHS HHSN268201700003CNHLBI NIH HHS HHSN268201700003INHLBI NIH HHS HHSN268201700004CNHLBI NIH HHS HHSN268201700004INHLBI NIH HHS HHSN268201800001CNHLBI NIH HHS HHSN268201800010INHLBI NIH HHS HHSN268201800011CNHLBI NIH HHS HHSN268201800011INHLBI NIH HHS HHSN268201800012CNHLBI NIH HHS HHSN268201800012INHLBI NIH HHS HHSN268201800014CNHLBI NIH HHS HHSN268201800014INHLBI NIH HHS HHSN268201800015INHLBI NIH HHS K23 HL140081NHLBI NIH HHS N01 HC025195NHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085086NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS R01 HL034594NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL117626NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R01 HL136574NHLBI NIH HHS R01 HL142599NHLBI NIH HHS R01 HL143224NHLBI NIH HHS R01 HL143295NHLBI NIH HHS R01 HL146636NHLBI NIH HHS R01 HL148050NHLBI NIH HHS R01 HL148565NHLBI NIH HHS R01 HL150170NHLBI NIH HHS R01 HL151283NHLBI NIH HHS RC2 HL102419NHLBI NIH HHS T32 HL007208NHLBI NIH HHS T32 HL129982NHLBI NIH HHS U01 HL080295NHLBI NIH HHS U01 HL120393NHLBI NIH HHS U01 HL130114NIA NIH HHS P30 AG066546NIA NIH HHS R01 AG023629NIA NIH HHS R01 AG049607NIA NIH HHS R01 AG054076NIA NIH HHS R01 AG058969NIA NIH HHS R01 AG066134NIA NIH HHS R01 AG067513NIA NIH HHS RF1 AG059421NIA NIH HHS U01 AG052409NIDA NIH HHS HHSN271201700002CNIDDK NIH HHS P30 DK063491NIEHS NIH HHS P30 ES010126NIGMS NIH HHS T32 GM136651NIH HHS DP5 OD029586NIMHD NIH HHS HHSN268201800013ININDS NIH HHS R01 NS017950NINDS NIH HHS R01 NS114045NINDS NIH HHS UH2 NS100605NINDS NIH HHS UH3 NS100605WHI NIH HHS 75N92021D00003WHI NIH HHS 75N92021D00004WHI NIH HHS 75N92021D00005WHI NIH HHS HHSN268201100001C
Abstract
background and purposeClonal hematopoiesis of indeterminate potential (CHIP) is a novel age-related risk factor for cardiovascular disease-related morbidity and mortality. The association of CHIP with risk of incident ischemic stroke was reported previously in an exploratory analysis including a small number of incident stroke cases without replication and lack of stroke subphenotyping. The purpose of this study was to discover whether CHIP is a risk factor for ischemic or hemorrhagic stroke.
methodsWe utilized plasma genome sequence data of blood DNA to identify CHIP in 78 752 individuals from 8 prospective cohorts and biobanks. We then assessed the association of CHIP and commonly mutated individual CHIP driver genes (
resultsCHIP was associated with an increased risk of total stroke (hazard ratio, 1.14 [95% CI, 1.03-1.27];
conclusionsCHIP is associated with an increased risk of stroke, particularly with hemorrhagic and small vessel ischemic stroke. Future studies clarifying the relationship between CHIP and subtypes of stroke are needed.
Indexed as
AdultAgedAged, 80 and overClonal HematopoiesisDioxygenasesDNA-Binding ProteinsDNA Methyltransferase 3AFemaleHemorrhagic StrokeHumansIncidenceIschemic StrokeMaleMiddle AgedPrevalenceRepressor ProteinsASXL1 protein, humanDioxygenasesDNA-Binding ProteinsDNA Methyltransferase 3ARepressor ProteinsTET2 protein, humanbrain ischemiacardiovascular diseasesclonal hematopoiesishumansprospective studies
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