ArticleAnnals of rehabilitation medicine2021
Post-stroke Hyperglycemia in Non-diabetic Ischemic Stroke is Related With Worse Functional Outcome: A Cohort Study.
Article in Annals of rehabilitation medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Impact of Stress-Induced Hyperglycemia on In-Hospital Medical Complications in Patients With Acute Stroke: From a Large-Scale Nationwide Longitudinal Registry.Annals of clinical and translational neurology · 2026Article
- Association of stroke with possible sarcopenic obesity and the modified effect from healthy lifestyle: a cross-sectional study based on CHARLS.BMC public health · 2025Article
- High Glucose Aggravates Cerebral Ischemia/Reperfusion via Truncated NLRP3-Mediated Hexokinase-2 Translocation.CNS neuroscience & therapeutics · 2025Article
- Autonomic dysfunction after stroke: an overview of recent clinical evidence and perspectives on therapeutic management.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Review
- Stress Hyperglycemia as a Prognostic Indicator of the Clinical Outcomes in Patients with Stroke: A Comprehensive Literature Review.Biomedicines · 2025Review
- Stroke and associated comorbidities in Southeast Asian countries.Neuroprotection (Chichester, England) · 2025Review
- A comparative analysis of the cholesterol-high-density lipoprotein-glucose index and the triglyceride-glucose index in predicting in-hospital mortality in critically ill ischemic stroke patients.Frontiers in neurology · 2025Article
- Stress hyperglycemia increases short-term mortality in acute ischemic stroke patients after mechanical thrombectomy.Diabetology & metabolic syndrome · 2024Article
- The Role of Nondiabetic Hyperglycemia in Critically Ill Patients with Acute Ischemic Stroke.Journal of clinical medicine · 2022Article
- Implications of fasting plasma glucose variability on the risk of incident peripheral artery disease in a population without diabetes: a nationwide population-based cohort study.Cardiovascular diabetology · 2022Article
- A Path to Precision Medicine: Incorporating Blood-Based Biomarkers in Stroke Rehabilitation.Annals of rehabilitation medicine · 2021Article
Corrections and comments
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Authors and funding
13 authors at 10 institutions in 1 country.
Funding
Abstract
objectiveTo investigate long-term and serial functional outcomes in ischemic stroke patients without diabetes with post-stroke hyperglycemia.
methodsThe Korean Stroke Cohort for Functioning and Rehabilitation (KOSCO) is a large, multi-center, prospective cohort study of stroke patients admitted to participating hospitals in nine areas of Korea. From KOSCO, ischemic stroke patients without diabetes were recruited and divided into two groups: patients without diabetes without (n=779) and with post-stroke hyperglycemia (n=223). Post-stroke hyperglycemia was defined as a glucose level >8 mmol/L. Functional assessments were performed 7 days and 3, 6, and 12 months after stroke onset.
resultsThere were no significant differences in baseline characteristics between the groups, except in the age of onset and smoking. Analysis of the linear correlation between the initial National Institutes of Health Stroke Scale (NIHSS) score and glucose level showed no significant difference. Among our functional assessments, NIHSS, Fugl-Meyer Assessment (affected side), Functional Ambulatory Category, modified Rankin Scale, and Korean Mini-Mental State Examination (K-MMSE) showed statistically significant improvements in each group. All functional improvements except K-MMSE were significantly higher in patients without post-stroke hyperglycemia at 7 days and 3, 6, and 12 months.
conclusionThe glucose level of ischemic stroke patients without diabetes had no significant correlation with the initial NIHSS score. The long-term effects of stress hyperglycemia showed worse functional outcomes in ischemic stroke patients without diabetes with post-stroke hyperglycemia.
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