Evidence map›Paper›PMID 34743323›Full record

ArticleThe Journal of comparative neurology2022

Retinal patterns and the cellular repertoire of neuropsin (Opn5) retinal ganglion cells.

Shane P D'Souza, David I Swygart, Sophia R Wienbar, Brian A Upton, Kevin X Zhang, Robert D Mackin, Anna K Casasent, Melanie A Samuel, Gregory W Schwartz, Richard A Lang

Open access · hybridAbstract read
In one paragraph

Article in The Journal of comparative neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Minimal Mimics and Maps of Natural Light for Mammals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  3. Article
  4. Review
  5. The physiological functions of OPN5m.Eye and vision (London, England) · 2025
    Review
  6. Review
  7. Article
  8. Hypothalamic opsin 3 suppresses MC4R signaling and potentiates Kir7.1 to promote food consumption.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Retinorecipient areas in the common marmoset (Frontiers in neural circuits · 2023
    Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Shane P D'SouzaMolecular and Developmental Biology Graduate Program, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA.ORCID 0000-0001-6344-1434
David I SwygartDepartments of Ophthalmology and Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Sophia R WienbarDepartments of Ophthalmology and Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Brian A UptonMolecular and Developmental Biology Graduate Program, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA.
Kevin X ZhangMolecular and Developmental Biology Graduate Program, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA.
Robert D MackinDepartment of Neuroscience, Huffington Center on Aging, Baylor College of Medicine, Houston, Texas, USA.
Anna K CasasentDepartment of Neuroscience, Huffington Center on Aging, Baylor College of Medicine, Houston, Texas, USA.
Melanie A SamuelDepartment of Neuroscience, Huffington Center on Aging, Baylor College of Medicine, Houston, Texas, USA.
Gregory W SchwartzDepartments of Ophthalmology and Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Richard A LangThe Visual Systems Group, Division of Pediatric Ophthalmology, Center for Chronobiology, Abrahamson Pediatric Eye Institute, Cincinnati, Ohio, USA.
Baylor College of Medicine · USNorthwestern University · USUniversity of Cincinnati · USCincinnati Children's Hospital Medical Center · USUniversity of Cincinnati Medical Center · US

Funding

Regulation of vascular development in the eye by an opsin 5-dependent clockR01EY027077 · NEI · CINCINNATI CHILDRENS HOSP MED CTR · PI LANG, RICHARD A., RAO, SUJATA · 2016 to 2020
$2.4M
Novel circuit mapping strategies to reverse engineer the retinaDP2EY026770 · NEI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SCHWARTZ, GREGORY WILLIAM · 2015 to 2015
$2.3M
Regulation of eye development by an Opsin5-dopamine pathwayR01EY027711 · NEI · EMORY UNIVERSITY · PI IUVONE, P MICHAEL, LANG, RICHARD A. · 2017 to 2020
$1.9M
Light regulated vascular development in the eye via the Hippo pathwayR01EY032029 · NEI · CINCINNATI CHILDRENS HOSP MED CTR · PI LANG, RICHARD A., XIN, MEI · 2021 to 2024
$1.6M
Functional Divergence at the Mouse Type 6 Bipolar Cell TerminalF31EY030344 · NEI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SWYGART, DAVID ISAIAH · 2019 to 2021
$137k
Intrinsic electrical properties shape feature selectivity in a novel retinal ganglion cellF31EY030737 · NEI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI WIENBAR, SOPHIA ROSE · 2019 to 2021
$130k
NEI NIH HHS DP2 EY026770NEI NIH HHS F31 EY030344NEI NIH HHS F31 EY030737NEI NIH HHS R01 EY027077NEI NIH HHS R01 EY027711NEI NIH HHS R01 EY032029
6 · The paper itself

Abstract

Obtaining a parts list of the sensory components of the retina is vital to understand the effects of light in behavior, health, and disease. Rods, cones, and intrinsically photosensitive retinal ganglion cells (ipRGCs) are the best described photoreceptors in the mammalian retina, but recent functional roles have been proposed for retinal neuropsin (Opn5)-an atypical opsin. However, little is known about the pattern of Opn5 expression in the retina. Using cre (Opn5

Indexed as

RetinaRetinal Ganglion CellsAnimalsMammalsMembrane ProteinsMiceOpsinsRetinal Cone Photoreceptor CellsRod OpsinsMembrane ProteinsOPN5 protein, mouseOpsinsRod Opsins

Identifiers

PMID34743323
PMCPMC8969148
OpenAlexW3213136455

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.