Evidence map›Paper›PMID 34743265›Full record

ArticleInternational journal of clinical oncology2022

COVID-19 infection in pediatric patients treated for cancer.

Lital Oz-Alcalay, Sarah Elitzur, Nofar Amitai, Helen Toledano, Shlomit Barzilai-Birenboim, Gali Avrahami, Gil Gilad, Yoav Vardi, Michal Dvori, Shai Izraeli and 2 more

Erratum issuedAbstract read
In one paragraph

Article in International journal of clinical oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Lital Oz-AlcalayDepartment A, Hematology-Oncology Schneider Children's Medical Center of Israel, Petach Tikva, Israel.
Sarah ElitzurDepartment of Hematology-Oncology, Schneider Children's Medical Center of Israel, Petach Tikva, Israel.
Nofar AmitaiDepartment A, Hematology-Oncology Schneider Children's Medical Center of Israel, Petach Tikva, Israel.
Helen ToledanoDepartment of Hematology-Oncology, Schneider Children's Medical Center of Israel, Petach Tikva, Israel.
Shlomit Barzilai-BirenboimDepartment of Hematology-Oncology, Schneider Children's Medical Center of Israel, Petach Tikva, Israel.
Gali AvrahamiDepartment of Hematology-Oncology, Schneider Children's Medical Center of Israel, Petach Tikva, Israel.
Gil GiladDepartment of Hematology-Oncology, Schneider Children's Medical Center of Israel, Petach Tikva, Israel.
Yoav VardiDepartment of Hematology-Oncology, Schneider Children's Medical Center of Israel, Petach Tikva, Israel.
Michal DvoriDepartment of Hematology-Oncology, Schneider Children's Medical Center of Israel, Petach Tikva, Israel.
Shai IzraeliDepartment of Hematology-Oncology, Schneider Children's Medical Center of Israel, Petach Tikva, Israel.
Gilat LivniDepartment A, Hematology-Oncology Schneider Children's Medical Center of Israel, Petach Tikva, Israel.
Oded GiladDepartment of Hematology-Oncology, Schneider Children's Medical Center of Israel, Petach Tikva, Israel. dkgsguss@gmail.com.ORCID http://orcid.org/0000-0002-0033-3425

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCOVID-19, the novel coronavirus, has caused a global pandemic affecting millions of people around the world. Risk factors for critical disease in adults are advanced age and underlying medical comorbidities, including cancer. Data are sparse on the effect of COVID-19 infection on pediatric patients with cancer during their active antineoplastic therapy. The optimal management of antineoplastic treatment during COVID-19 infection in this unique population is controversial.

aimTo describe the severity and clinical course of COVID-19 infection in pediatric patients with cancer during active antineoplastic treatment and to study their course of treatment.

methodsClinical and laboratory data were collected from medical files of patients diagnosed with COVID-19, confirmed by polymerase chain reaction (PCR), who received active antineoplastic treatment between March 2020 and May 2021 in a large tertiary pediatric medical center.

resultsEighteen patients with diverse pediatric cancers are described. They were infected with COVID-19 at different stages of their antineoplastic treatment regimen. Eight had an asymptomatic COVID-19 infection, nine had mild symptoms, and one had severe disease. All of them recovered from COVID-19 infection. Two patients experienced delays in their antineoplastic treatment; none of the other patients had delays or interruptions, including patients who were symptomatic for COVID-19.

conclusionIn pediatric patients with cancer who test positive for COVID-19, yet are asymptomatic or have mild symptoms, the continuance of antineoplastic therapy may be considered.

Indexed as

Antineoplastic AgentsCOVID-19NeoplasmsAdultChildHumansPandemicsSARS-CoV-2Antineoplastic AgentsAntineoplastic therapyCancerCOVID-19Pediatric patients

Identifiers

PMID34743265
PMCPMC8572073

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.