SynthesisActa diabetologica2022
Global burden of early pregnancy gestational diabetes mellitus (eGDM): A systematic review.
Synthesis in Acta diabetologica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Early-Onset Versus Late-Onset Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis of Maternal, Perinatal and Neonatal Outcomes.Diabetes, obesity & metabolism · 2026Pooled it
- Gestational Diabetes Mellitus and Adverse Maternal and Neonatal Health Outcomes: an Umbrella review of Meta-Analyses.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026Pooled it
- Self-care practices among women with gestational diabetes in low-resource settings in Ghana: a phenomenological study.Scientific reports · 2026Article
- Immune dysregulation in gestational diabetes mellitus: placental downregulation of CXCL9 and IL1RL1 and altered immune cell infiltration.Frontiers in cell and developmental biology · 2026Article
- Comprehensive Review of Gestational Diabetes: Pathophysiology, Pharmacological Management and the Role of Pharmaceutical Care.Current drug safety · 2026Review
- Perinatal and postpartum insulin secretion capacity in women with early-onset and late-onset gestational diabetes.BMJ open diabetes research & care · 2025Article
- Prevalence of gestational diabetes mellitus in India: The ICMR-INDIAB national study (ICMR-INDIAB-24).The Indian journal of medical research · 2025Article
- Article
- Early Gestational Diabetes Mellitus Diagnosis: A Strategy for Mitigating Excessive Maternal Weight Gain-LINDA-Brasil Study.Nutrients · 2025Article
- Continuous glucose monitoring system in diabetes in pregnancy: a narrative review.Diabetology & metabolic syndrome · 2025Review
- Evidence Gap and Knowledge Map of Early Gestational Diabetes Mellitus (eGDM) Screening in India: A Scoping Review.Current diabetes reports · 2025Article
- Retrospective cohort study on treatment outcomes of early vs late onset gestational diabetes mellitus.Acta diabetologica · 2025Article
- The Maternal and Fetal Consequences of Metabolic Dysfunction-Associated Fatty Liver Disease and Gestational Diabetes Mellitus.Nutrients · 2025Review
- Metabolic profiling and early prediction models for gestational diabetes mellitus in PCOS and non-PCOS pregnant women.European journal of medical research · 2025Article
- Gestational diabetes in early pregnancy is associated with postpartum glucose intolerance: A perspective from the diabetes and pregnancy outcome for mother and baby study in Japan.Journal of diabetes investigation · 2025Article
- Association between the new TyG indicator-TyHGB and gestational diabetes mellitus: results from the case-control and prospective cohort studies.Journal of translational medicine · 2025Article
- Predictors of Cardiometabolic Health a Few Months Postpartum in Women Who Had Developed Gestational Diabetes.Nutrients · 2025Observational
- Research Progress of Risk Factors Associated with Gestational Diabetes Mellitus.Endocrine, metabolic & immune disorders drug targets · 2025Review
- The potential causal effect of the pre-pregnancy dietary phytochemical index on gestational diabetes mellitus: a prospective cohort study.BMC pregnancy and childbirth · 2024Article
- Metformin Inefficiency to Lower Lipids in Vitamin B12 Deficient HepG2 Cells Is Alleviated via Adiponectin-AMPK Axis.Nutrients · 2023Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 4 countries.
Funding
Abstract
aimsGestational diabetes mellitus (GDM) diagnosed during the first trimester of pregnancy is called 'early pregnancy Gestational Diabetes Mellitus' (eGDM). The burden of eGDM has only been studied sporadically. This review aims to understand the global burden of eGDM in terms of prevalence, risk factors, pregnancy outcomes, treatment and postpartum dysglycemia.
methodsA review of epidemiologic studies reporting on early GDM screening as per Joanna Briggs Institute (JBI) methodology for prevalence reviews was conducted. A customized search strategy was used to search electronic databases namely, PubMed, CINAHL, EMBASE, Cochrane Library, Scopus, MEDLINE, Ovid, ScienceDirect, and Google Scholar. Three independent reviewers reviewed studies using Covidence software. Observational studies irrespective of study design and regardless of diagnostic criteria were included. Quality of evidence was appraised, and findings were synthesized.
resultsOf 58 included studies, 41 reported a prevalence of eGDM, ranging from 0.7 to 36.8%. Body mass index (BMI), previous history of GDM, family history of diabetes and multiparity were reported as eGDM risk factors. Adverse pregnancy outcomes associated with eGDM were macrosomia, caesarean delivery, induction of labour, hypertension, preterm delivery, and shoulder dystocia. The incidence of postpartum dysglycemia and the need for insulin was higher in women with eGDM. The risk of bias was moderate. Heterogeneity of studies is a limitation. Meta-analysis was not performed.
conclusionsThere is heterogeneity in the prevalence of eGDM and intrapartum and postpartum ill effects for the mother and the offspring. There is a need to develop a universal screening protocol for eGDM.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.