Evidence map›Paper›PMID 34743019›Full record

ArticleNanomedicine : nanotechnology, biology, and medicine2022

Optical biosensing of markers of mucosal inflammation.

Obdulia Covarrubias-Zambrano, Massoud Motamedi, Bill T Ameredes, Bing Tian, William J Calhoun, Yingxin Zhao, Allan R Brasier, Madumali Kalubowilage, Aruni P Malalasekera, Asanka S Yapa and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanomedicine : nanotechnology, biology, and medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Early Detection of Pancreatic Cancers Using Liquid Biopsies and Hierarchical Decision Structure.IEEE journal of translational engineering in health and medicine · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Obdulia Covarrubias-ZambranoDepartment of Chemistry, Kansas State University, Manhattan, KS, USA.
Massoud MotamediCenter for Biomedical Engineering, University of Texas Medical Branch, Galveston, TX, USA.
Bill T AmeredesInstitute for Translational Sciences and Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX.
Bing TianInstitute for Translational Sciences and Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX.
William J CalhounInstitute for Translational Sciences and Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX.
Yingxin ZhaoInstitute for Translational Sciences and Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX.
Allan R BrasierInstitute for Clinical and Translational Research, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, WI.
Madumali KalubowilageDepartment of Chemistry, Kansas State University, Manhattan, KS, USA.
Aruni P MalalasekeraDepartment of Chemistry, Southwestern College, 100 College Street, Winfield, KS, USA.
Asanka S YapaDepartment of Chemistry, Kansas State University, Manhattan, KS, USA.
Hongwang WangDepartment of Chemistry, Kansas State University, Manhattan, KS, USA.
Christopher T CulbertsonDepartment of Chemistry, Kansas State University, Manhattan, KS, USA.
Deryl L TroyerDepartment of Anatomy & Physiology, Kansas State University, Manhattan, KS, USA.
Stefan H BossmannDepartment of Chemistry, Kansas State University, Manhattan, KS, USA; The University of Kansas Medical Center, Department of Cancer Biology and The University of Kansas Cancer Center, Kansas City, KS, USA. Electronic address: sbossmann@kumc.edu.
Kansas State University · USThe University of Texas Medical Branch at Galveston · USSouthwestern College - Kansas · USUniversity of Wisconsin–Madison · US

Funding

UTMB Clinical and Translational Science AwardUL1TR000071 · NCATS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI BRASIER, ALLAN R. · 2012 to 2014
$14.4M
UTMB Clinical and Translational Science AwardKL2TR001441 · NCATS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI AMEREDES, BILL T · 2015 to 2024
$4.0M
Mechanisms of Steroid Resistance in Severe AsthmaR01HL069130 · NHLBI · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI CALHOUN, WILLIAM J. · 2001 to 2005
$2.6M
Development of novel quantitative methods for in vivo assessment of mucosal irritR01AI112015 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI MOTAMEDI, MASSOUD, VARGAS, GRACIE · 2014 to 2017
$2.4M
The Role of IL-10 in Regulation of Allergic InflammationR01HL063738 · NHLBI · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI AMEREDES, BILL T · 2002 to 2009
$1.7M
NCATS NIH HHS KL2 TR001441NCATS NIH HHS UL1 TR000071NHLBI NIH HHS R01 HL063738NHLBI NIH HHS R01 HL069130NIAID NIH HHS R01 AI112015
6 · The paper itself

Abstract

We report the design and adaptation of iron/iron oxide nanoparticle-based optical nanobiosensors for enzymes or cytokine/chemokines that are established biomarkers of lung diseases. These biomarkers comprise ADAM33, granzyme B, MMP-8, neutrophil elastase, arginase, chemokine (C-C motif) ligand 20 and interleukin-6. The synthesis of nanobiosensors for these seven biomarkers, their calibration with commercially available enzymes and cytokines/chemokines, as well as their validation using bronchoalveolar lavage (BAL) obtained from a mouse model of TLR3-mediated inflammation are discussed here. Exhaled Breath Condensate (EBC) is a minimally invasive approach for sampling airway fluid in the diagnosis and management of various lung diseases in humans (e.g., asthma, COPD and viral infections). We report the proof-of-concept of using human EBC in conjunction with nanobiosensors for diagnosis/monitoring airway inflammation. These findings suggest that, with nanosensor technology, human EBC can be utilized as a liquid biopsy to monitor inflammation/remodeling in lung disease.

Indexed as

AsthmaLung DiseasesAnimalsBiomarkersBreath TestsInflammationMiceBiomarkersIron/iron oxide core/shell nanoparticleLung inflammationNanodiagnosticsNanomedicineOptical biosensor

Identifiers

PMID34743019
PMCPMC9127977
OpenAlexW3209166351

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.