ArticleNeuroImage2021
Neurons in the human medial temporal lobe track multiple temporal contexts during episodic memory processing.
Article in NeuroImage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- Neural dynamics underlying minute-timescale persistent behaviour in the human brain.Nature human behaviour · 2026Article
- Hippocampal Drift Rate Reflects the Temporal Organization of Memories.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
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- Cholinergic blockade reveals a role for human hippocampal theta in memory encoding but not retrieval.bioRxiv : the preprint server for biology · 2025Article
- Theta-phase locking of single neurons during human spatial memory.Nature communications · 2025Article
- Human single-neuron activity is modulated by intracranial theta burst stimulation of the basolateral amygdala.bioRxiv : the preprint server for biology · 2025Article
- Heterogeneous tau deposition patterns in the preclinical stage link to domain-specific cognitive deficits.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Human neural dynamics of real-world and imagined navigation.Nature human behaviour · 2025Article
- The moderating role of information processing speed in the relationship between brain remodeling and episodic memory in amnestic mild cognitive impairment.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Concept and location neurons in the human brain provide the 'what' and 'where' in memory formation.Nature communications · 2024Article
- Multiscale Functional Connectivity analysis of episodic memory reconstruction.Frontiers in cognition · 2024Article
- Neurophysiological mechanisms of cognition in the developing brain: Insights from intracranial EEG studies.Developmental cognitive neuroscience · 2023Review
- Acetylcholine modulates the temporal dynamics of human theta oscillations during memory.Nature communications · 2023Article
- Article
- Effect of APOE4 Allele and Gender on the Rate of Atrophy in the Hippocampus, Entorhinal Cortex, and Fusiform Gyrus in Alzheimer's Disease.Current Alzheimer research · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Episodic memory requires associating items with temporal context, a process for which the medial temporal lobe (MTL) is critical. This study uses recordings from 27 human subjects who were undergoing surgical intervention for intractable epilepsy. These same data were also utilized in Umbach et al. (2020). We identify 103 memory-sensitive neurons in the hippocampus and entorhinal cortex, whose firing rates predicted successful episodic memory encoding as subjects performed a verbal free recall task. These neurons exhibit important properties. First, as predicted from the temporal context model, they demonstrate reinstatement of firing patterns observed during encoding at the time of retrieval. The magnitude of reinstatement predicted the tendency of subjects to cluster retrieved memory items according to input serial position. Also, we found that spiking activity of these neurons was locked to the phase of hippocampal theta oscillations, but that the mean phase of spiking shifted between memory encoding versus retrieval. This unique observation is consistent with predictions of the "Separate Phases at Encoding And Retrieval (SPEAR)" model. Together, the properties we identify for memory-sensitive neurons characterize direct electrophysiological mechanisms for the representation of contextual information in the human MTL.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.