Evidence map›Paper›PMID 34742545›Full record

ReviewBiological psychiatry2022

Current and Future Perspectives of Noncoding RNAs in Brain Function and Neuropsychiatric Disease.

Evan J Kyzar, John Peyton Bohnsack, Subhash C Pandey

Open access · greenAbstract readReview
In one paragraph

Review in Biological psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 25 citations in OpenAlex.

  1. The role ofEpigenetics · 2026
    Review
  2. mNature reviews. Neuroscience · 2026
    Review
  3. Article
  4. Review
  5. Article
  6. Hallmarks of Brain Plasticity.Biomedicines · 2025
    Review
  7. Article
  8. Article
  9. LncRNA CCRR maintains CaScience China. Life sciences · 2024
    Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Review
  15. Review
  16. Decoding microRNAs in autism spectrum disorder.Molecular therapy. Nucleic acids · 2022
    Review
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Evan J KyzarCenter for Alcohol Research in Epigenetics, Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois; Department of Psychiatry, Columbia University Irving Medical Center, New York State Psychiatric Institute, New York, New York.
John Peyton BohnsackCenter for Alcohol Research in Epigenetics, Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois.
Subhash C PandeyCenter for Alcohol Research in Epigenetics, Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois; Jesse Brown Veterans Affairs Medical Center, University of Illinois at Chicago, Chicago, Illinois; Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, Illinois. Electronic address: scpandey@uic.edu.
University of Illinois Chicago · US

Funding

Pilot Project Program P50AA022538 · NIAAA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Katherine Miles Johnston McMurray · 2015 to 2026
$21.3M
Role of AIE in Epigenetic and Behavioral Changes at AdulthoodU01AA019971 · NIAAA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI PANDEY, SUBHASH C. · 2010 to 2024
$5.6M
PRIMING THE PUMP: TRAINING PHYSICIAN-SCIENTISTS IN TRANSLATIONAL PSYCHIATRYR25MH086466 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI Melissa Arbuckle, Eduardo David Leonardo · 2009 to 2026
$4.3M
2/2 NADIA U24 Epigenetic/Molecular CoreU24AA024605 · NIAAA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI PANDEY, SUBHASH C. · 2015 to 2024
$3.6M
Signaling Mechanisms in Alcohol Drinking BehaviorsR01AA010005 · NIAAA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI PANDEY, SUBHASH C. · 2001 to 2017
$3.0M
Neuronal PARP activity in fetal alcohol spectrum disordersR01AA025035 · NIAAA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI PANDEY, SUBHASH C. · 2017 to 2021
$1.8M
Cellular signaling in alcoholismI01BX004517 · VA · JESSE BROWN VA MEDICAL CENTER · PI PANDEY, SUBHASH C. · 2019 to 2023
–
BLRD VA I01 BX004517NIAAA NIH HHS P50 AA022538NIAAA NIH HHS R01 AA010005NIAAA NIH HHS R01 AA025035NIAAA NIH HHS U01 AA019971NIAAA NIH HHS U24 AA024605NIMH NIH HHS R25 MH086466
6 · The paper itself

Abstract

Noncoding RNAs (ncRNAs) represent the majority of the transcriptome and play important roles in regulating neuronal functions. ncRNAs are exceptionally diverse in both structure and function and include enhancer RNAs, long ncRNAs, and microRNAs, all of which demonstrate specific temporal and regional expression in the brain. Here, we review recent studies demonstrating that ncRNAs modulate chromatin structure, act as chaperone molecules, and contribute to synaptic remodeling and behavior. In addition, we discuss ncRNA function within the context of neuropsychiatric diseases, particularly focusing on addiction and schizophrenia, and the recent methodological developments that allow for better understanding of ncRNA function in the brain. Overall, ncRNAs represent an underrecognized molecular contributor to complex neuronal processes underlying neuropsychiatric disorders.

Indexed as

MicroRNAsRNA, Long NoncodingBrainHumansNeurocognitive DisordersRNA, UntranslatedMicroRNAsRNA, Long NoncodingRNA, UntranslatedAddictionEpigeneticseRNAlncRNAmiRNAncRNAPsychiatric disorders

Identifiers

PMID34742545
PMCPMC8959010
OpenAlexW3194299058

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.