ArticleGenes and environment : the official journal of the Japanese Environmental Mutagen Society2021
Associations between ADIPOQ rs2241766 SNP and breast cancer risk: a systematic review and a meta-analysis.
Article in Genes and environment : the official journal of the Japanese Environmental Mutagen Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- A bioinformatics approach of specificity protein transcription factors in head and neck squamous cell carcinoma.Research in pharmaceutical sciences · 2024Article
- Correlation between adiponectin rs2241766 and rs266729 polymorphisms and risk of papillary thyroid cancer.Molecular biology research communications · 2022Article
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Authors and funding
4 authors.
Funding
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Abstract
purposeWe aimed to conduct a meta-analysis to accurately evaluate the potential association between ADIPOQ rs2241766 gene SNP and breast cancer risk.
methodsA systematic literature search on Cochrane Library, PubMed, Embase, Web of Science and China National Knowledge Infrastructure (CNKI) identified 8 articles with 1692 cases and 1890 controls. Strength of association was evaluated by pooled odds ratio (OR), 95 % confidence interval (CI) and p value. Funnel plots and Begger's regression test were applied for testing the publication bias. Statistical analysis of all data was performed by Stata 12.0.
resultsThe meta-analysis results indicated that the ADIPOQ rs2241766 gene polymorphism did not significantly associated with the risk of breast cancer for these genetic models (TT vs. TG + GG: OR = 1.20, 95 % CI = 0.77-1.89, p=0.417; TT + TG vs. GG: OR = 1.05, 95 % CI = 0.71-1.56, p=0.805; T vs. G: OR =1.17, 95 % CI = 0.79-1.74, p=0.437).
conclusionsThis study indicated that no significant relationship between the ADIPOQ rs2241766 SNP and breast cancer. Further large-scale and well-designed studies will be indispensable to confirm our result.
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