ArticleBiosensors & bioelectronics2022
SERS-PCR assays of SARS-CoV-2 target genes using Au nanoparticles-internalized Au nanodimple substrates.
Article in Biosensors & bioelectronics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 57 citations in OpenAlex.
- Surface-Enhanced Raman Spectroscopy for Viral Diagnostics: Principles, Strategies, Clinical Challenges, and Future Directions.Chemical reviews · 2026Review
- Microfluidic-optical integrated portable platform with handheld pump for wash-free plasmonic detection of thrombin and SARS-CoV-2 spike protein.Microsystems & nanoengineering · 2026Article
- Research progress, translation-related challenges, and clinical prospects of surface-enhanced Raman spectroscopy in respiratory virus detection: a narrative review.Journal of thoracic disease · 2026Review
- SERS-based aptasensor for culture-free detection of Escherichia coli in urinary tract infection diagnosis.Nano convergence · 2025Article
- Rapid antigen test based on gold nanoparticles embedded with highly sensitive surface-enhanced Raman scattering probes for detecting antigen concentrations below the visual detection limit.Mikrochimica acta · 2025Article
- Nanozyme-active Au@Pt NRs array SERS platform based on a recognition competition strategy for convenient and ultrasensitive detection of miR-106a-5p associated with cerebral infarction.Biomedical optics express · 2025Article
- Low power density, high-efficiency reflective Raman system for polymer SERS substrates.RSC advances · 2024Article
- Construction of PCR-SERS Method for Detection ofFoods (Basel, Switzerland) · 2024Article
- The Application of Biomaterials for the Vaccine, Treatment, and Detection of SARS-CoV-2.ACS omega · 2024Review
- Dual-clamped one-pot SERS-based biosensors for rapid and sensitive detection of SARS-CoV-2 using portable Raman spectrometer.Sensors and actuators. B, Chemical · 2023Article
- Article
- Label-free detection and discrimination of respiratory pathogens based on electrochemical synthesis of biomaterials-mediated plasmonic composites and machine learning analysis.Biosensors & bioelectronics · 2023Article
- SERS combined with PCR as a potent tool for detecting mutations: a case study of tomato plants.RSC advances · 2022Article
- One-pot and rapid detection of SARS-CoV-2 viral particles in environment using SERS aptasensor based on a locking amplifier.Sensors and actuators. B, Chemical · 2022Article
- Recent Advances of Representative Optical Biosensors for Rapid and Sensitive Diagnostics of SARS-CoV-2.Biosensors · 2022Review
- AuNP-based biosensors for the diagnosis of pathogenic human coronaviruses: COVID-19 pandemic developments.Analytical and bioanalytical chemistry · 2022Review
- Nanoplasmonic multiplex biosensing for COVID-19 vaccines.Biosensors & bioelectronics · 2022Article
- N protein-based ultrasensitive SARS-CoV-2 antibody detection in seconds via 3D nanoprinted, microarchitected array electrodes.Journal of medical virology · 2022Article
- Surface-enhanced Raman scattering-based immunoassay for severe acute respiratory syndrome coronavirus 2.Biosensors & bioelectronics · 2022Article
- Bridging pandemic and oncology challenges: Surface-enhanced Raman spectroscopy in the fight against COVID-19 and cancer.Science progressReview
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The reverse transcription-polymerase chain reaction (RT-PCR) method has been adopted worldwide to diagnose severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although this method has good sensitivity and specificity, there is a need to develop a more rapid diagnostic technology, given the virus's rapid spread. However, the RT-PCR method takes a long time to diagnose SARS-CoV-2 because of the required thermocycling steps. Therefore, we developed a surface-enhanced Raman scattering (SERS)-PCR detection method using an AuNP-internalized Au nanodimple substrate (AuNDS) to shorten the diagnosis time by reducing the number of thermocycling steps needed to amplify the DNA. For the representative target markers, namely, the envelope protein (E) and RNA-dependent RNA polymerase (RdRp) genes of SARS-CoV-2, 25 RT-PCR thermocycles are required to reach a detectable threshold value, while 15 cycles are needed for magnetic bead-based SERS-PCR when the initial DNA concentration was 1.00× 10
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.