ArticleNeuron2022
Neocortex saves energy by reducing coding precision during food scarcity.
Article in Neuron, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed, 90 citations in OpenAlex.
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- Coherent-resonant netting: disorder-enhanced selectivity from transient wave-like dynamics on biological connectomes.Frontiers in computational neuroscience · 2026Article
- Awareness of being: a computational neurophenomenological model of mindfulness, mind-wandering, and meta-attentional control.Neuroscience of consciousness · 2026Article
- Beyond lifespan and healthspan: a biological framework for experienced longevity.Frontiers in aging neuroscience · 2026Article
- The role of MICOS in modulating mitochondrial dynamics and structural changes in vulnerable regions of Alzheimer's Disease.bioRxiv : the preprint server for biology · 2025Article
- ATP Metabolism of Astrocytes: Consumption, Regeneration and Restoration.Neurochemical research · 2025Review
- Frugal inference for control.ArXiv · 2025Article
- Quantifying the link between retinal performance and the optomotor response.Current biology : CB · 2025Article
- A tactile discrimination task to study neuronal dynamics in freely-moving mice.Nature communications · 2025Article
- Potential downsides of calorie restriction.Nature reviews. Endocrinology · 2025Review
- A Pilot Study on the Effect of Added Sugar on Response Inhibition: Event-Related Potentials in a Go/NoGo Task.Medicina (Kaunas, Lithuania) · 2025Article
- Cooperative breeding and the selection for information sharing among groupmates.Behavioral ecology and sociobiology · 2025Article
- Exploring subthreshold processing for next-generation TinyAI.Frontiers in computational neuroscience · 2025Article
- Selective learning for sensing using shift-invariant spectrally stable undersampled networks.Scientific reports · 2024Article
- Diverting glial glycolytic flux towards neurons is a memory-relevant role of Drosophila CRH-like signalling.Nature communications · 2024Article
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4 authors at 1 institution in 1 country.
Funding
Abstract
Information processing is energetically expensive. In the mammalian brain, it is unclear how information coding and energy use are regulated during food scarcity. Using whole-cell recordings and two-photon imaging in layer 2/3 mouse visual cortex, we found that food restriction reduced AMPA receptor conductance, reducing synaptic ATP use by 29%. Neuronal excitability was nonetheless preserved by a compensatory increase in input resistance and a depolarized resting potential. Consequently, neurons spiked at similar rates as controls but spent less ATP on underlying excitatory currents. This energy-saving strategy had a cost because it amplified the variability of visually-evoked subthreshold responses, leading to a 32% broadening of orientation tuning and impaired fine visual discrimination. This reduction in coding precision was associated with reduced levels of the fat mass-regulated hormone leptin and was restored by exogenous leptin supplementation. Our findings reveal that metabolic state dynamically regulates the energy spent on coding precision in neocortex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.