Evidence map›Paper›PMID 34741648›Full record

ArticleEuropean journal of nutrition2022

Fine-grained investigation of the relationship between human nutrition and global DNA methylation patterns.

Fabrizia Noro, Annalisa Marotta, Marialaura Bonaccio, Simona Costanzo, Federica Santonastaso, Sabatino Orlandi, Alfonsina Tirozzi, Roberta Parisi, Amalia De Curtis, Mariarosaria Persichillo and 9 more

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In one paragraph

Article in European journal of nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 3 institutions in 1 country.

Fabrizia NoroDepartment of Epidemiology and Prevention, IRCCS NEUROMED, Via dell'Elettronica, 86077, Pozzilli, IS, Italy.ORCID http://orcid.org/0000-0002-4754-9303
Annalisa MarottaDepartment of Epidemiology and Prevention, IRCCS NEUROMED, Via dell'Elettronica, 86077, Pozzilli, IS, Italy.ORCID http://orcid.org/0000-0002-9217-1506
Marialaura BonaccioDepartment of Epidemiology and Prevention, IRCCS NEUROMED, Via dell'Elettronica, 86077, Pozzilli, IS, Italy.ORCID http://orcid.org/0000-0002-8082-6552
Simona CostanzoDepartment of Epidemiology and Prevention, IRCCS NEUROMED, Via dell'Elettronica, 86077, Pozzilli, IS, Italy.ORCID http://orcid.org/0000-0003-4569-1186
Federica SantonastasoDepartment of Epidemiology and Prevention, IRCCS NEUROMED, Via dell'Elettronica, 86077, Pozzilli, IS, Italy.
Sabatino OrlandiDepartment of Epidemiology and Prevention, IRCCS NEUROMED, Via dell'Elettronica, 86077, Pozzilli, IS, Italy.ORCID http://orcid.org/0000-0002-9498-173X
Alfonsina TirozziDepartment of Epidemiology and Prevention, IRCCS NEUROMED, Via dell'Elettronica, 86077, Pozzilli, IS, Italy.ORCID http://orcid.org/0000-0002-6052-1807
Roberta ParisiDepartment of Epidemiology and Prevention, IRCCS NEUROMED, Via dell'Elettronica, 86077, Pozzilli, IS, Italy.ORCID http://orcid.org/0000-0003-3789-3490
Amalia De CurtisDepartment of Epidemiology and Prevention, IRCCS NEUROMED, Via dell'Elettronica, 86077, Pozzilli, IS, Italy.ORCID http://orcid.org/0000-0001-5104-0318
Mariarosaria PersichilloDepartment of Epidemiology and Prevention, IRCCS NEUROMED, Via dell'Elettronica, 86077, Pozzilli, IS, Italy.
Francesco GianfagnaMediterranea Cardiocentro, Naples, Italy.ORCID http://orcid.org/0000-0003-4615-0816
Augusto Di CastelnuovoMediterranea Cardiocentro, Naples, Italy.ORCID http://orcid.org/0000-0001-9767-7998
Maria Benedetta DonatiDepartment of Epidemiology and Prevention, IRCCS NEUROMED, Via dell'Elettronica, 86077, Pozzilli, IS, Italy.ORCID http://orcid.org/0000-0003-1747-5443
Chiara CerlettiDepartment of Epidemiology and Prevention, IRCCS NEUROMED, Via dell'Elettronica, 86077, Pozzilli, IS, Italy.ORCID http://orcid.org/0000-0002-4759-3179
Giovanni de GaetanoDepartment of Epidemiology and Prevention, IRCCS NEUROMED, Via dell'Elettronica, 86077, Pozzilli, IS, Italy.ORCID http://orcid.org/0000-0002-7823-1402
Licia IacovielloDepartment of Epidemiology and Prevention, IRCCS NEUROMED, Via dell'Elettronica, 86077, Pozzilli, IS, Italy. licia.iacoviello@moli-sani.org.ORCID http://orcid.org/0000-0003-0514-5885
Alessandro Gialluisi *Department of Epidemiology and Prevention, IRCCS NEUROMED, Via dell'Elettronica, 86077, Pozzilli, IS, Italy.ORCID http://orcid.org/0000-0002-7388-4463
Benedetta Izzi *Department of Epidemiology and Prevention, IRCCS NEUROMED, Via dell'Elettronica, 86077, Pozzilli, IS, Italy.ORCID http://orcid.org/0000-0002-3649-7931
Moli-sani Study Investigators
Istituto Neurologico Mediterraneo · ITUniversity of Insubria · ITClinica Mediterranea · IT

Funding

Italian Ministry of University and Research (MIUR, Rome, Italy)- Programma Triennale di Ricerca Decreto no.1588
6 · The paper itself

Abstract

purposeNutrition is an important, modifiable, environmental factor affecting human health by modulating epigenetic processes, including DNA methylation (5mC). Numerous studies investigated the association of nutrition with global and gene-specific DNA methylation and evidences on animal models highlighted a role in DNA hydroxymethylation (5hmC) regulation. However, a more comprehensive analysis of different layers of nutrition in association with global levels of 5mC and 5hmC is lacking. We investigated the association between global levels of 5mC and 5hmC and human nutrition, through the stratification and analysis of dietary patterns into different nutritional layers: adherence to Mediterranean diet (MD), main food groups, macronutrients and micronutrients intake.

methodsELISA technique was used to measure global 5mC and 5hmC levels in 1080 subjects from the Moli-sani cohort. Food intake during the 12 months before enrolment was assessed using the semi-quantitative EPIC food frequency questionnaire. Complementary approaches involving both classical statistics and supervised machine learning analyses were used to investigate the associations between global 5mC and 5hmC levels and adherence to Mediterranean diet, main food groups, macronutrients and micronutrients intake.

resultsWe found that global DNA methylation, but not hydroxymethylation, was associated with daily intake of zinc and vitamin B3. Random Forests algorithms predicting 5mC and 5hmC through intakes of food groups, macronutrients and micronutrients revealed a significant contribution of zinc, while vitamin B3 was reported among the most influential features.

conclusionWe found that nutrition may affect global DNA methylation, suggesting a contribution of micronutrients previously implicated as cofactors in methylation pathways.

Indexed as

5-MethylcytosineDNA MethylationAnimalsEpigenesis, GeneticHumansNutritional Status5-MethylcytosineFood groupsGlobal DNA methylationMediterranean dietMicronutrientsVitamin B3Zinc

Identifiers

PMID34741648
OpenAlexW3212554052

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.