ReviewPsychopharmacology2022
Associations between cannabis use, cannabis use disorder, and mood disorders: longitudinal, genetic, and neurocognitive evidence.
Review in Psychopharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 4 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Effectiveness of psychosocial interventions for adults with substance use disorder that have a co-occurring mental health disorder: an umbrella review and illustrative cost-effectiveness analysis.Health technology assessment (Winchester, England) · 2026Pooled it
- Cannabis use among Arab students: a systematic review.Frontiers in psychiatry · 2025Pooled it
- Causal relationship between cannabis use and cancer: a genetically informed perspective.Journal of cancer research and clinical oncology · 2023Pooled it
- Unhealthy behaviors associated with mental health disorders: a systematic comparative review of diet quality, sedentary behavior, and cannabis and tobacco use.Frontiers in public health · 2023Pooled it
- Acute and Extended Anxiolytic Effects of Cannabidiol in Cannabis Flower: A Quasi-ExperimentalCannabis and cannabinoid research · 2024Trial
- [Effectiveness of a cannabis prevention program in school: results of a randomized prospective study].Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz · 2024Trial
- Association between problematic internet use and depressive symptoms among individuals at high-risk of cannabis use disorder: a cross-sectional study in Quebec (Canada).Addictive behaviors reports · 2026Article
- Longitudinal Effects of Cannabis Use on Suicidal Behaviour in Early Adulthood in Washington State, United States and Victoria, Australia.Prevention science : the official journal of the Society for Prevention Research · 2026Article
- Article
- Use of cannabis to regulate negative affect in pregnancy: Bidirectional findings from an ecological momentary assessment study.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2026Article
- Mental health consequences of contemporary cannabis use in Europe: potency, patterns of use, and health system context.Frontiers in psychiatry · 2026Review
- Developing an online cannabis store paradigm for Cannabis Regulatory Science.medRxiv : the preprint server for health sciences · 2025Article
- Examining bidirectional associations between cannabis use and internalizing symptoms among high-risk emerging adults: A prospective cohort study.Psychological medicine · 2025Article
- Association Between Cannabis Use and Neuropsychiatric Disorders: A Two-sample Mendelian Randomization Study.Alpha psychiatry · 2025Article
- Leveraging Genomic Data to Examine the Causal Impact of Alcohol, Tobacco, Cannabis, and Opioid Use on Biological and Cognitive Ageing.Addiction biology · 2025Article
- Investigating Lifestyle Risk and Protective Factors for Depression in Young Adults: Insights From a Large-Scale Cross-Sectional Study.American journal of lifestyle medicine · 2025Article
- The role of sex in the association between cannabis use disorder and resting-state functional connectivity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Comorbid Cannabis Use and Mood Disorders Among Adolescents.Focus (American Psychiatric Publishing) · 2025Review
- Persistent increased severity of cannabis use disorder symptoms in adolescents compared to adults: a one-year longitudinal study.European archives of psychiatry and clinical neuroscience · 2025Observational
- Cannabis and psychopathology: 2024 Snapshot of a meandering journey.Indian journal of psychiatry · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
rationaleCannabis use among people with mood disorders increased in recent years. While comorbidity between cannabis use, cannabis use disorder (CUD), and mood disorders is high, the underlying mechanisms remain unclear.
objectivesWe aimed to evaluate (1) the epidemiological evidence for an association between cannabis use, CUD, and mood disorders; (2) prospective longitudinal, genetic, and neurocognitive evidence of underlying mechanisms; and (3) prognosis and treatment options for individuals with CUD and mood disorders.
methodsNarrative review of existing literature is identified through PubMed searches, reviews, and meta-analyses. Evidence was reviewed separately for depression, bipolar disorder, and suicide.
resultsCurrent evidence is limited and mixed but suggestive of a bidirectional relationship between cannabis use, CUD, and the onset of depression. The evidence more consistently points to cannabis use preceding onset of bipolar disorder. Shared neurocognitive mechanisms and underlying genetic and environmental risk factors appear to explain part of the association. However, cannabis use itself may also influence the development of mood disorders, while others may initiate cannabis use to self-medicate symptoms. Comorbid cannabis use and CUD are associated with worse prognosis for depression and bipolar disorder including increased suicidal behaviors. Evidence for targeted treatments is limited.
conclusionsThe current evidence base is limited by the lack of well-controlled prospective longitudinal studies and clinical studies including comorbid individuals. Future studies in humans examining the causal pathways and potential mechanisms of the association between cannabis use, CUD, and mood disorder comorbidity are crucial for optimizing harm reduction and treatment strategies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.