ArticleAnnals of neurology2022
Optimal Surgical Extent for Memory and Seizure Outcome in Temporal Lobe Epilepsy.
Article in Annals of neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
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Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Pooled it
- Roles of fMRI and Wada tests in the presurgical evaluation of language functions in temporal lobe epilepsy.Frontiers in neurology · 2022Pooled it
- Serum neurofilament light and MRI predictors of cognitive decline in patients with secondary progressive multiple sclerosis: Analysis from the MS-STAT randomised controlled trial.Multiple sclerosis (Houndmills, Basingstoke, England) · 2022Trial
- Predicting post-surgical visuospatial memory performance in people with drug-resistant epilepsy.Epileptic disorders : international epilepsy journal with videotape · 2026Article
- Spatiotemporal dynamics of seizure networks: Progressive posterior hippocampal recruitment in mesial temporal lobe epilepsy.Epilepsia · 2026Article
- Face-name associative memory in temporal lobe epilepsy: Region-specific insights in right-hemisphere onset.Epilepsy research · 2026Article
- Perirhinal cortex gains control of hippocampal seizures via broad downstream circuits in male mouse models.Nature communications · 2026Article
- Mesial temporal lobe epilepsy with hippocampal sclerosis: Seizure, neuropsychological, and quality of life outcomes of 100 patients treated with trans-anterior T1 selective amygdalohippocampectomy.Epileptic disorders : international epilepsy journal with videotape · 2026Article
- Thalamic organization differentially contributes to clinical conditions in epilepsy.Communications medicine · 2026Article
- White matter resection and verbal memory deficits after temporal lobe epilepsy surgery.Brain communications · 2026Article
- Metabolic connectivity and memory in mesial temporal lobe epilepsy.Brain communications · 2026Article
- Personalized neurometabolic signature predicts seizure outcomes of laser ablation in mesial temporal lobe epilepsy.Communications medicine · 2025Article
- Multi-voxel pattern analysis of face and word encoding fMRI in people with temporal lobe epilepsy and healthy individuals.Epilepsy & behavior : E&B · 2025Article
- Combined impact of gray and superficial white matter abnormalities: Implications for epilepsy surgery.Epilepsia · 2025Article
- The upside of epilepsy: Theories of an evolutionary paradox.Epilepsia open · 2025Review
- Article
- Relationship of left piriform cortex network centrality with temporal lobe epilepsy duration and drug resistance.European journal of neurology · 2025Article
- Long-term memory plasticity in a decade-long connectivity study post anterior temporal lobe resection.Nature communications · 2025Article
- Cortico-hippocampal networks underpin verbal memory encoding in temporal lobe epilepsy.Brain communications · 2025Article
- Anatomical aspects, technical nuances, and a case series of the resection of the inferior temporal gyrus as a strategy to access the basal surface of the temporal lobe and the lateral incisural space.Surgical neurology international · 2025Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 3 countries.
Funding
Abstract
objectivePostoperative memory decline is an important consequence of anterior temporal lobe resection (ATLR) for temporal lobe epilepsy (TLE), and the extent of resection may be a modifiable factor. This study aimed to define optimal resection margins for cognitive outcome while maintaining a high rate of postoperative seizure freedom.
methodsThis cohort study evaluated the resection extent on postoperative structural MRI using automated voxel-based methods and manual measurements in 142 consecutive patients with unilateral drug refractory TLE (74 left, 68 right TLE) who underwent standard ATLR.
resultsVoxel-wise analyses revealed that postsurgical verbal memory decline correlated with resections of the posterior hippocampus and inferior temporal gyrus, whereas larger resections of the fusiform gyrus were associated with worsening of visual memory in left TLE. Limiting the posterior extent of left hippocampal resection to 55% reduced the odds of significant postoperative verbal memory decline by a factor of 8.1 (95% CI 1.5-44.4, p = 0.02). Seizure freedom was not related to posterior resection extent, but to the piriform cortex removal after left ATLR. In right TLE, variability of the posterior extent of resection was not associated with verbal and visual memory decline or seizures after surgery.
interpretationThe extent of surgical resection is an independent and modifiable risk factor for cognitive decline and seizures after left ATLR. Adapting the posterior extent of left ATLR might optimize postoperative outcome, with reduced risk of memory impairment while maintaining comparable seizure-freedom rates. The current, more lenient, approach might be appropriate for right ATLR. ANN NEUROL 2022;91:131-144.
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