Evidence map›Paper›PMID 34741447›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2022

Biostack: Nontoxic Metabolite Detection from Live Tissue.

Xenofon Strakosas, Mary J Donahue, Adel Hama, Marcel Braendlein, Miriam Huerta, Daniel T Simon, Magnus Berggren, George G Malliaras, Roisin M Owens

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Ionic-Bionic Interfaces: Advancing Iontronic Strategies for Bioelectronic Sensing and Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Biostack: Nontoxic Metabolite Detection from Live Tissue.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xenofon StrakosasLaboratory of Organic Electronics, Department of Science and Technology, Linköping University, Norrköping, 601 74, Sweden.ORCID 0000-0001-5757-8565
Mary J DonahueLaboratory of Organic Electronics, Department of Science and Technology, Linköping University, Norrköping, 601 74, Sweden.
Adel HamaKing Abdullah University of Science and Technology, KAUST, Thuwal, 23955-6900, Saudi Arabia.
Marcel BraendleinPanaxium, Aix en Provence, 13100, France.
Miriam HuertaRobert F. Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY, 14853, USA.
Daniel T SimonLaboratory of Organic Electronics, Department of Science and Technology, Linköping University, Norrköping, 601 74, Sweden.
Magnus BerggrenLaboratory of Organic Electronics, Department of Science and Technology, Linköping University, Norrköping, 601 74, Sweden.
George G MalliarasElectrical Engineering Division, University of Cambridge, Cambridge, CB3 0FA, UK.
Roisin M OwensDepartment of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, UK, USA.

Funding

ANR-TEuropean Research Council 258966European Research Council ERC-2010-StGIONOSENSE
6 · The paper itself

Abstract

There is increasing demand for direct in situ metabolite monitoring from cell cultures and in vivo using implantable devices. Electrochemical biosensors are commonly preferred due to their low-cost, high sensitivity, and low complexity. Metabolite detection, however, in cultured cells or sensitive tissue is rarely shown. Commonly, glucose sensing occurs indirectly by measuring the concentration of hydrogen peroxide, which is a by-product of the conversion of glucose by glucose oxidase. However, continuous production of hydrogen peroxide in cell media with high glucose is toxic to adjacent cells or tissue. This challenge is overcome through a novel, stacked enzyme configuration. A primary enzyme is used to provide analyte sensitivity, along with a secondary enzyme which converts H

Indexed as

Biosensing TechniquesCells, CulturedGlucoseHumansHydrogen PeroxideGlucoseHydrogen Peroxidebiofunctionalizationbiosensorsglucose monitoringorganic bioelectronicsorganic electrochemical transistors

Identifiers

PMID34741447
PMCPMC8805579

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.