ArticleJournal of the American Geriatrics Society2022
Persistence of pain and cognitive impairment in older adults.
Article in Journal of the American Geriatrics Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- Chronic pain and risk of cognitive impairment: a meta-analysis of longitudinal cohort studies.Translational psychiatry · 2026Pooled it
- Longitudinal associations of pain and cognitive decline in community-dwelling older adults.Psychology and aging · 2022Trial
- Article
- Nursing Home Profit Status and Pain Among Residents Living With Dementia.Pain management nursing : official journal of the American Society of Pain Management Nurses · 2026Article
- Associations between pain and cognitive impairment in older adults: findings from the birjand longitudinal aging study.Aging clinical and experimental research · 2026Article
- Trajectories of pain and cognitive function: 22 years of evidence in mid-to-later life.medRxiv : the preprint server for health sciences · 2026Article
- Dual Experience and Management of Pain in Older Adults and Their Caregivers.Clinics in geriatric medicine · 2026Review
- Unmet health-related social needs are associated with pain outcomes among midlife and older adults.Frontiers in pain research (Lausanne, Switzerland) · 2026Article
- Article
- The role of transcutaneous auricular vagus nerve stimulation in chronic pain: from neurobiological mechanisms to clinical applications.Frontiers in pain research (Lausanne, Switzerland) · 2026Review
- Limited Australian clinical guidelines for pain assessment in hospitalized older adults with cognitive impairment: implications for safe and quality care.Frontiers in pain research (Lausanne, Switzerland) · 2026Review
- Transitions in Sarcopenia Status and Cognitive Trajectories Among Middle-Aged and Older Adults in China: Longitudinal Cohort Study.JMIR aging · 2025Article
- High-impact pain predicts subjective cognitive decline and interacts with APOE4 genotype in the development of objective cognitive impairment.The journal of pain · 2025Article
- Longitudinal associations between multimodal symptom clusters and functional disability in older adults: a comparative cohort analysis using SHARE, ELSA, and KLoSA.Scientific reports · 2025Article
- Chronic pain and subjective memory problems are dynamic risk factors for functional decline: An ACTIVE longitudinal study.Experimental gerontology · 2025Article
- Longitudinal online weekly reports of non-cognitive symptoms and events can differentiate incident mild cognitive impairment from stable cognitively healthy older adults.Journal of Alzheimer's disease : JAD · 2025Article
- Development and testing of a predictive model of symptoms for pain in community-dwelling frail older people in palliative care.BMC palliative care · 2025Observational
- Longitudinal MRI identifies associations between cognitive decline, inflammatory markers, and hippocampal subregion volumes in individuals with knee osteoarthritis.Communications medicine · 2025Article
- Associations Between Physical Activity Frequency, Handgrip Strength, and Limitations in Activities of Daily Living in Middle-Aged and Older Adults with Widespread Pain: A Cross-Sectional Study Using Data from the SHARE Project.Geriatrics (Basel, Switzerland) · 2025Article
- High-impact chronic pain and cognitive decline among Mexicans aged 60 and older from 2012 to 2018.The journal of pain · 2025Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundNo studies have examined the longitudinal association between the persistence of pain and its relationship to cognitive problems in older adults. The objective of this study was to examine how the persistent of pain associates with cognitive performance, cognitive impairment, and subjective memory decline.
methodsAcross 10 biennial waves, 8515 adults ages 65 and over were assessed from the Health and Retirement Study (M
resultsPersistence of pain presence was associated with an increased risk of cognitive impairment. Only persistence of pain interference, not pain intensity, was significantly associated with poorer cognitive performance or being classified as cognitively impaired. For every 2 years, persistence of pain interference was associated with 21% increased odds of cognitive impairment. Only one of three pain variables was related to incident subjective memory decline.
conclusionsPersistence of pain is associated with poorer cognitive performance in community-dwelling older adults, especially when involving ongoing interference in chores and work. Facilitating pain management might be important for helping to maintain later-life cognition and reduce dementia risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.