ReviewNature reviews. Urology2022
Simulating nature in sperm selection for assisted reproduction.
Review in Nature reviews. Urology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07093619 (Evaluating the Utility of Implementing Microfluids for Sperm Preparation Compared to Conventional Method of Density Gradient Centrifugation in a PGT-A Program), which is not on this map. Cited by 42 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluating the Utility of Implementing Microfluids for Sperm Preparation Compared to Conventional Method of Density Gradient Centrifugation in a PGT-A Program: a Sibling Oocyte Study
Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- Artificial vagina conformation and composition for semen collection.Reproduction & fertility · 2025Pooled it
- Impact of semen quality on the risk of direct cleavage in human embryos.Journal of assisted reproduction and genetics · 2026Observational
- Article
- Functional heterogeneity of sperm binding to the ZP2 N terminus across normospermic and infertile phenotypes.Journal of translational medicine · 2026Article
- Proteostasis, Assisted Reproductive Technologies, and Neurodevelopmental Differences: An Integrative Perspective.Proteomes · 2026Review
- Sperm hyperactivation drives a circling-and-wandering swimming behavior.Nature communications · 2026Article
- In vitro fertilization outcomes in previously cured tuberculosis patients: a retrospective study.Archives of gynecology and obstetrics · 2026Article
- Female reproductive tract-on-a-chip for selecting sperm with ultra-low DNA fragmentation index.Microsystems & nanoengineering · 2026Article
- Sperm Testing in Assisted Reproductive Technology: Diagnosis and Outcome Prediction.Reproductive sciences (Thousand Oaks, Calif.) · 2026Review
- From reservoir to rendezvous: the journey of sperm through the oviduct.Reproduction, fertility, and development · 2026Review
- Sperm DNA fragmentation and assisted reproduction: an umbrella meta-analysis.European journal of medical research · 2026Article
- A large-scale prediction model to predict large for gestational age infants conceived by IVF/ICSI.Frontiers in endocrinology · 2026Article
- Effect of Adding Human Umbilical Cord Mesenchymal Stem Cells-Derived Secretome on Sperm Quality Improvement by Swim-Up Method.Obstetrics and gynecology international · 2026Article
- Semenogelin I-derived peptide SgI-52 binds membrane Peroxiredoxin 6 and induces oxidative stress in asthenozoospermic sperm.Reproductive biology and endocrinology : RB&E · 2025Article
- Automated AI for real-time sperm selection in ICSI: reducing variability and studying the role of sperm in embryo development.Reproductive biology and endocrinology : RB&E · 2025Observational
- Integration of Bioengineered Tools in Assisted Reproductive Technologies.Advanced healthcare materials · 2025Review
- Microfluidic Sorting Can Be Applied for Assisted Reproduction Sperm Selection in Different Cases of Semen Abnormalities.Life (Basel, Switzerland) · 2025Article
- A Comprehensive Comparison of PICSI and ICSI Techniques Through a Triple-Blinded Trial: Effects on Embryo Quality, Cumulative Pregnancy Rate, and Live Birth Rate.Biomedicines · 2025Article
- Label-free metabolic fingerprinting of motile mammalian spermatozoa with subcellular resolution.BMC biology · 2025Article
- Porcine sperm bind to an oviduct glycan coupled to glass surfaces as a model of sperm interaction with the oviduct.Scientific reports · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sperm selection in the female reproductive tract (FRT) is sophisticated. Only about 1,000 sperm out of millions in an ejaculate reach the fallopian tube and thus have a chance of fertilizing an oocyte. In assisted reproduction techniques, sperm are usually selected using their density or motility, characteristics that do not reflect their fertilization competence and, therefore, might result in failure to fertilize the oocyte. Although sperm processing in in vitro fertilization (IVF) and intrauterine insemination (IUI) bypasses many of the selection processes in the FRT, selection by the cumulus mass and the zona pellucida remain intact. By contrast, the direct injection of a sperm into an oocyte in intracytoplasmic sperm injection (ICSI) bypasses all natural selection barriers and, therefore, increases the risk of transferring paternal defects such as fragmented DNA and genomic abnormalities in sperm to the resulting child. Research into surrogate markers of fertilization potential and into simulating the natural sperm selection processes has progressed. However, methods of sperm isolation - such as hyaluronic acid-based selection and microfluidic isolation based on sperm tactic responses - use only one or two parameters and are not comparable with the multistep sperm selection processes naturally occurring within the FRT. Fertilization-competent sperm require a panel of molecules, including zona pellucida-binding proteins and ion channel proteins, that enable them to progress through the FRT to achieve fertilization. The optimal artificial sperm selection method will, therefore, probably need to use a multiparameter tool that incorporates the molecular signature of sperm with high fertilization potential, and their responses to external cues, within a microfluidic system that can replicate the physiological processes of the FRT in vitro.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.