Evidence map›Paper›PMID 34741033›Full record

ArticleCell death & disease2021

Tenomodulin knockout mice exhibit worse late healing outcomes with augmented trauma-induced heterotopic ossification of Achilles tendon.

Manuel Delgado Caceres, Katharina Angerpointner, Michael Galler, Dasheng Lin, Philipp A Michel, Christoph Brochhausen, Xin Lu, Adithi R Varadarajan, Jens Warfsmann, Richard Stange and 3 more

Open access · goldAbstract read
In one paragraph

Article in Cell death & disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 36 citations in OpenAlex.

  1. Piezo2FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  2. Article
  3. Comparative Analysis of Tendon Healing in a Clinically Relevant Mouse Model of Achilles Tendon Repair.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Muscle Contraction Is Essential for Tendon Healing and Muscle Function Recovery After Achilles Tendon Rupture and Surgical Repair.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025
    Article
  9. Article
  10. Tendon mechanobiology in the context of tendon biofabrication.Frontiers in bioengineering and biotechnology · 2025
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
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  18. iPSC-derived tenocytes seeded on microgrooved 3D printed scaffolds for Achilles tendon regeneration.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 1 country.

Manuel Delgado CaceresExperimental Trauma Surgery, Department of Trauma Surgery, University Regensburg Medical Centre, Regensburg, Germany.
Katharina AngerpointnerHand, Elbow and Plastic Surgery Department, Schön Klinik München Harlaching, Munich, Germany.
Michael GallerDepartment of Trauma Surgery, Caritas Hospital St. Josef, Regensburg, Germany.
Dasheng LinOrthopaedic Center of People's Liberation Army, The Affiliated Southeast Hospital of Xiamen University, Zhangzhou, China.
Philipp A MichelDepartment of Trauma-, Hand-, and Reconstructive Surgery, University Hospital Münster, Münster, Germany.
Christoph BrochhausenInstitute of Pathology, University of Regensburg, Regensburg, Germany.
Xin LuDivision of Personalized Tumor Therapy, Fraunhofer Institute for Toxicology and Experimental Medicine, Regensburg, Germany.
Adithi R VaradarajanDivision of Personalized Tumor Therapy, Fraunhofer Institute for Toxicology and Experimental Medicine, Regensburg, Germany.
Jens WarfsmannDivision of Personalized Tumor Therapy, Fraunhofer Institute for Toxicology and Experimental Medicine, Regensburg, Germany.
Richard StangeDepartment of Regenerative Musculoskeletal Medicine, Institute for Musculoskeletal Medicine, University Hospital Münster, Westfälische Wilhelms-University, Münster, Germany.
Volker AltExperimental Trauma Surgery, Department of Trauma Surgery, University Regensburg Medical Centre, Regensburg, Germany.
Christian G PfeiferExperimental Trauma Surgery, Department of Trauma Surgery, University Regensburg Medical Centre, Regensburg, Germany.
Denitsa DochevaExperimental Trauma Surgery, Department of Trauma Surgery, University Regensburg Medical Centre, Regensburg, Germany. denitsa.docheva@ukr.de.ORCID http://orcid.org/0000-0002-7588-1290
Fraunhofer Institute for Toxicology and Experimental Medicine · DEUniversity Hospital Regensburg · DEUniversity Hospital Münster · DECaritas-Krankenhaus St. Josef · DESchön Klinik München Harlaching · DEUniversity of Regensburg · DEUniversity of Würzburg · DE

Funding

Deutsche Forschungsgemeinschaft (German Research Foundation) DO1414/3-1
6 · The paper itself

Abstract

Heterotopic ossification (HO) represents a common problem after tendon injury with no effective treatment yet being developed. Tenomodulin (Tnmd), the best-known mature marker for tendon lineage cells, has important effects in tendon tissue aging and function. We have reported that loss of Tnmd leads to inferior early tendon repair characterized by fibrovascular scaring and therefore hypothesized that its lack will persistently cause deficient repair during later stages. Tnmd knockout (Tnmd

Indexed as

Wound HealingAchilles TendonActinsAnimalsBromodeoxyuridineCell CountChondrogenesisCicatrixElasticityElastic ModulusExtracellular MatrixFibrillar CollagensGenotypeGreen Fluorescent ProteinsInflammationMacrophagesActa2 protein, mouseActinsBromodeoxyuridineFibrillar CollagensGreen Fluorescent ProteinsMembrane ProteinsTnmd protein, mouse

Identifiers

PMID34741033
PMCPMC8571417
OpenAlexW3208438498

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.