ArticleNature communications2021
Insecticide resistance by a host-symbiont reciprocal detoxification.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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Who cites it
35 citing papers in PubMed, 98 citations in OpenAlex.
- An engineered bacterial symbiont maps micron-scale sugar gradients in the honeybee gut.PLoS biology · 2026Article
- Symbiotic Stenotrophomonas maltophilia is associated with ivermectin resistance in the parasitic nematode Haemonchus contortus via metabolic detoxification.International journal for parasitology. Drugs and drug resistance · 2026Article
- Parental Broflanilide Exposure Impairs Offspring Fitness and Alters Detoxification Enzymes and Gut Microbiota inInsects · 2026Article
- Article
- Characterization of Gut Bacteria inInsects · 2026Article
- Symbiont-mediated mechanisms of insecticide resistance in insects.Journal of insect science (Online) · 2026Review
- Review
- Transformation of 3-(4-methoxybenzylidine)-5-(RSC advances · 2026Article
- Pyrethroids and organophosphate resistance in Aedes aegypti (Diptera: Culicidae) and their underlying mechanisms.Parasites & vectors · 2026Article
- Gut Microbe-Driven Resistance Mechanisms in Propylea Japonica: Insights from Horizontal Gene Transfer and Oxidative Phosphorylation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Host species-specific gene expression by a widespread and flexible chemosynthetic symbiont.The ISME journal · 2026Article
- Complex Roles of Insect Cytochrome P450s in Chemical Adaptation.International journal of biological sciences · 2026Review
- Mechanisms and Genetic Drivers of Resistance of Insect Pests to Insecticides and Approaches to Its Control.Toxics · 2025Review
- Gut microbiota-mediated lipid accumulation as a driver of evolutionary adaptation to blue light toxicity in Drosophila.Communications biology · 2025Article
- Evaluation of hesperidin as a potential larvicide against Culex pipiens with computational prediction of its mode of action via molecular docking.Scientific reports · 2025Article
- Cooperative microbial metabolism enhances tryptophan-mediated insecticide detoxification in the fall armyworm.The ISME journal · 2025Article
- Elimination ofFrontiers in microbiology · 2025Article
- Unveiling detoxifying symbiosis and dietary influence on the Southern green shield bug microbiota.FEMS microbiology ecology · 2024Article
- Large-Scale Sampling Reveals the Strain-Level Diversity ofMicroorganisms · 2024Article
- Geographical, Seasonal, and Growth-Related Dynamics of Gut Microbiota in a Grapevine Pest, Apolygus spinolae (Heteroptera: Miridae).Microbial ecology · 2024Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Insecticide resistance is one of the most serious problems in contemporary agriculture and public health. Although recent studies revealed that insect gut symbionts contribute to resistance, the symbiont-mediated detoxification process remains unclear. Here we report the in vivo detoxification process of an organophosphorus insecticide, fenitrothion, in the bean bug Riptortus pedestris. Using transcriptomics and reverse genetics, we reveal that gut symbiotic bacteria degrade this insecticide through a horizontally acquired insecticide-degrading enzyme into the non-insecticidal but bactericidal compound 3-methyl-4-nitrophenol, which is subsequently excreted by the host insect. This integrated "host-symbiont reciprocal detoxification relay" enables the simultaneous maintenance of symbiosis and efficient insecticide degradation. We also find that the symbiont-mediated detoxification process is analogous to the insect genome-encoded fenitrothion detoxification system present in other insects. Our findings highlight the capacity of symbiosis, combined with horizontal gene transfer in the environment, as a powerful strategy for an insect to instantly eliminate a toxic chemical compound, which could play a critical role in the human-pest arms race.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.