Evidence map›Paper›PMID 34740979›Full record

ArticleRMD open2021

Impact of axial spondyloarthritis on mental health in Europe: results from the EMAS study.

Marco Garrido-Cumbrera, David Gálvez-Ruiz, Carlos J Delgado-Domínguez, Denis Poddubnyy, Victoria Navarro-Compán, Laura Christen, Raj Mahapatra, Souzi Makri, Christine Bundy, EMAS working group

Open access · goldAbstract read
In one paragraph

Article in RMD open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

  1. Guideline
  2. Mendel randomization confirmed gastroesophageal reflux disease may increase the risk of mental disorders.Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 4 countries.

Marco Garrido-CumbreraHealth and Territory Research (HTR), University of Seville, Sevilla, Spain mcumbrera@us.es.ORCID 0000-0001-9727-1189
David Gálvez-RuizHealth and Territory Research (HTR), University of Seville, Sevilla, Spain.
Carlos J Delgado-DomínguezHealth and Territory Research (HTR), University of Seville, Sevilla, Spain.
Denis PoddubnyyCharité Universitätsmedizin, Berlin, Germany.ORCID 0000-0002-4537-6015
Victoria Navarro-CompánUniversity Hospital La Paz, IdiPAZ, Madrid, Spain.
Laura ChristenPatient Engagement, Novartis Pharma AG, Basel, Switzerland.
Raj MahapatraAxial Spondyloarthritis International Federation (ASIF), London, UK.
Souzi MakriCyprus League Against Rheumatism, Nicosia, Cyprus.
Christine BundyCardiff University, Wales, UK.
EMAS working group
Universidad de Sevilla · ESCardiff University · GBGerman Rheumatism Research Centre · DEMultiple Sclerosis International Federation · GBNovartis (Switzerland) · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo determine the presence of mental disorder risk and associated factors in European patients with axial spondyloarthritis (axSpA).

methodsData from 2,166 patients with axSpA in 12 European countries were collected from 2017 to 2018 through the European Map of Axial Spondyloarthritis online survey. Risk of mental disorders was assessed using the 12-item General Health Questionnaire. Possible predictors included age, gender, relationship status, patient organisation membership, job status, educational level, Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), functional limitation (0-54) and self-reported depression or anxiety. Bivariate analyses were conducted to determine predictors of risk of mental disorders (Mann-Whitney and χ

results60.7% of patients reported risk of mental disorders: they were younger (41.7 vs 46.0 years), more likely female (68.2% vs 57.9%), unemployed (7.5% vs 2.7%), on temporary (15.9% vs 5.4%) or permanent sick leave (13.2% vs 8.0%), reported depression (45.2% vs 14.2%) or anxiety (41.3% vs 12.5%), higher disease activity (BASDAI ≥4; 87.6% vs 62.3%) and functional limitation (16.5 vs 10.8). The factors most associated with risk of mental disorders were disease activity (OR=2.80), reported depression (OR=2.42), anxiety (OR=2.39), being unemployed or on sick leave (OR=1.98), functional limitation (OR=1.02) and younger age (OR=0.97).

conclusionsCompared with the general population, patients with axSpA show disproportionately worse mental health associated mainly with disease activity and employment status. Healthcare professionals should pay close attention to patients with high disease activity and address internally or refer to specialist services, where appropriate to ensure optimal patient outcomes.

Indexed as

Axial SpondyloarthritisSpondylitis, AnkylosingAnxietyEuropeFemaleHumansMental Healthankylosingpatient reported outcome measurespsychologyspondylitis

Identifiers

PMID34740979
PMCPMC8573671
OpenAlexW3208964689

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.