Evidence map›Paper›PMID 34740961›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2021

Thymus-Derived CD4

Holger Winkels, Yanal Ghosheh, Kouji Kobiyama, William B Kiosses, Marco Orecchioni, Erik Ehinger, Vasantika Suryawanshi, Sara Herrera-De La Mata, Paola Marchovecchio, Thomas Riffelmacher and 6 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. CD8Nature reviews. Cardiology · 2026
    Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 2 countries.

Holger WinkelsLa Jolla Institute for Immunology, La Jolla, CA; holger.winkels@uk-koeln.de.ORCID 0000-0003-1333-2031
Yanal GhoshehLa Jolla Institute for Immunology, La Jolla, CA.
Kouji KobiyamaLa Jolla Institute for Immunology, La Jolla, CA.
William B KiossesLa Jolla Institute for Immunology, La Jolla, CA.
Marco OrecchioniLa Jolla Institute for Immunology, La Jolla, CA.
Erik EhingerLa Jolla Institute for Immunology, La Jolla, CA.ORCID 0000-0002-2823-439X
Vasantika SuryawanshiLa Jolla Institute for Immunology, La Jolla, CA.
Sara Herrera-De La MataLa Jolla Institute for Immunology, La Jolla, CA.ORCID 0000-0002-9519-9520
Paola MarchovecchioLa Jolla Institute for Immunology, La Jolla, CA.
Thomas RiffelmacherLa Jolla Institute for Immunology, La Jolla, CA.ORCID 0000-0002-0372-5272
Nicolas ThiaultLa Jolla Institute for Immunology, La Jolla, CA.
Mitchell KronenbergLa Jolla Institute for Immunology, La Jolla, CA.
Dennis WolfUniversity Hospital Freiburg, Freiburg, Germany; and.ORCID 0000-0003-1525-4348
Gregory SeumoisLa Jolla Institute for Immunology, La Jolla, CA.ORCID 0000-0002-8164-6852
Pandurangan VijayanandLa Jolla Institute for Immunology, La Jolla, CA.
Klaus LeyLa Jolla Institute for Immunology, La Jolla, CA.ORCID 0000-0001-9339-3672
La Jolla Institute for Immunology · USUniversity Medical Center Freiburg · DE

Funding

Transcriptional GenomicsP01HL088093 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WITZTUM, JOSEPH L. · 2008 to 2018
$26.4M
Myeloid cell interactions with T cells in atherosclerosisR01HL115232 · NHLBI · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI LEY, KLAUS F. · 2012 to 2018
$3.2M
Vaccination with MHC-II restricted ApoB100 peptides to prevent atherosclerosisR01HL121697 · NHLBI · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI LEY, KLAUS F. · 2015 to 2018
$1.8M
Illumina HiSeq 2500 Sequencing SystemS10OD016262 · OD · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI RAO, ANJANA · 2013 to 2013
$600k
Super-resolution confocal microscopeS10OD021831 · OD · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI LEY, KLAUS F. · 2017 to 2017
$566k
FACSAria II Cell SorterS10RR027366 · NCRR · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI CROFT, MICHAEL · 2011 to 2011
$514k
NCRR NIH HHS S10 RR027366NHLBI NIH HHS P01 HL088093NHLBI NIH HHS R01 HL115232NHLBI NIH HHS R01 HL121697NIH HHS S10 OD016262NIH HHS S10 OD021831
6 · The paper itself

Abstract

Double-positive CD4

Indexed as

Adipose TissueAnimalsAorta, ThoracicCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesDNA-Binding ProteinsFemaleMiceMice, Inbred C57BLMice, KnockoutNatural Killer T-CellsThymus GlandDNA-Binding ProteinsRag2 protein, mouse

Identifiers

PMID34740961
PMCPMC8612987
OpenAlexW3210266702

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.