Evidence map›Paper›PMID 34740953›Full record

Trial reportJournal of nuclear medicine : official publication, Society of Nuclear Medicine2022

Correlation of

Christine E Mona, Matthias R Benz, Firas Hikmat, Tristan R Grogan, Katharina Lueckerath, Aria Razmaria, Rana Riahi, Roger Slavik, Mark D Girgis, Giuseppe Carlucci and 5 more

Registry-linked trialOpen access · hybridAbstract readClinical Trial
In one paragraph

Trial report in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07337850 (FAP 2), which is not on this map. Cited by 84 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed, 3 pooled it
8.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07337850 recruitingnot on this mapstarted 2024, after this paper: background citation

FAP 2: Utility of Gallium-68-Fibroblast Activation Protein Inhibitor (FAPI) PET in Biliary Tract Cancers: A Prospective Study

TypeobservationalSponsorTata Memorial CentreRan2024 to 2026Enrolled60ConditionsGall Bladder Cancer, Intrahepatic Cholangiocarcinoma (Icc)Armsgallium-68-Fibroblast Activation Protein Inhibitor
3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 3 syntheses or guidelines pooled it, 141 citations in OpenAlex.

  1. Joint EANM-SNMMI guideline on the role of 2-[European journal of nuclear medicine and molecular imaging · 2024
    Guideline
  2. Pooled it
  3. Pooled it
  4. Assessment of liver fibrosis and tumor burden in hepatocellular carcinoma using [European journal of nuclear medicine and molecular imaging · 2026
    Trial
  5. The role of [European journal of nuclear medicine and molecular imaging · 2023
    Trial
  6. Review
  7. Comparative Performance ofMolecular imaging and radionuclide therapy · 2026
    Article
  8. [BMJ open · 2026
    Observational
  9. Translational Theranostics in Glioblastoma: FAPI-46 as a Precision Medicine Tool.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Article
  10. Review
  11. Review
  12. Assessment of CCR2 PET as a Biomarker for Head and Neck Squamous Cell Carcinoma.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Article
  13. FAP-targeted [European journal of nuclear medicine and molecular imaging · 2026
    Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Comparative Performance ofWorld journal of nuclear medicine · 2026
    Article
  19. Diagnostic Efficacy of FAPI-PET/CT Versus [Diagnostics (Basel, Switzerland) · 2026
    Review
  20. Article

24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Christine E MonaAhmanson Translational Theranostics Division, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, California; jcalais@mednet.ucla.edu cmona@mednet.ucla.edu.
Matthias R BenzAhmanson Translational Theranostics Division, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, California.
Firas HikmatAhmanson Translational Theranostics Division, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, California.
Tristan R GroganDepartment of Medicine Statistics Core, David Geffen School of Medicine, UCLA, Los Angeles, California.
Katharina LueckerathAhmanson Translational Theranostics Division, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, California.
Aria RazmariaAhmanson Translational Theranostics Division, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, California.
Rana RiahiDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California.
Roger SlavikAhmanson Translational Theranostics Division, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, California.
Mark D GirgisDivision of Surgical Oncology, Department of Surgery, David Geffen School of Medicine, UCLA, Los Angeles, California; and.
Giuseppe CarlucciAhmanson Translational Theranostics Division, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, California.
Kimberly A KellyDepartment of Biomedical Engineering, University of Virginia School of Engineering and Applied Sciences, and Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, Virginia.
Samuel W FrenchJonsson Comprehensive Cancer Center, UCLA, Los Angeles, California.
Johannes CzerninAhmanson Translational Theranostics Division, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, California.
David W DawsonJonsson Comprehensive Cancer Center, UCLA, Los Angeles, California.
Jeremie CalaisAhmanson Translational Theranostics Division, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, California; jcalais@mednet.ucla.edu cmona@mednet.ucla.edu.
UCLA Jonsson Comprehensive Cancer CenterUniversity of California, Los Angeles · USUniversity of Virginia · US

Funding

Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Samuel Wheeler French · 1985 to 2026
$134.5M
UCLA SPORE in Brain CancerP50CA211015 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Yvonne Yu-Hsuan Chen · 2017 to 2026
$25.2M
NCI NIH HHS P30 CA016042NCI NIH HHS P50 CA211015
6 · The paper itself

Abstract

Fibroblast activation protein (FAP)-expressing cancer-associated fibroblasts confer treatment resistance and promote metastasis and immunosuppression. Because FAP is overexpressed in many cancers, radiolabeled molecules targeting FAP are studied for their use as pancancer theranostic agents. This study aimed to establish the spectrum of FAP expression across various cancers by immunohistochemistry and to explore whether

Indexed as

Gallium RadioisotopesNeoplasmsFemaleHumansImmunohistochemistryPositron Emission Tomography Computed TomographyProspective StudiesTissue DistributionGallium Radioisotopes68Ga-FAPi-46cancerfibroblast activation proteinimmunohistochemistryPET/CT

Identifiers

PMID34740953
PMCPMC9258565
OpenAlexW3210491826

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.