Evidence map›Paper›PMID 34740886›Full record

Observational studyThe British journal of ophthalmology2023

Risk factors for microcystic macular oedema in glaucoma.

Golnoush Mahmoudinezhad, Diana Salazar, Esteban Morales, Peter Tran, Janet Lee, Jean-Pierre Hubschman, Kouros Nouri-Mahdavi, Joseph Caprioli

Open access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in The British journal of ophthalmology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Observational
  3. Article
  4. Observational
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Golnoush MahmoudinezhadOphthalmology, Glaucoma, University of California Los Angeles, Los Angeles, CA, USA.
Diana SalazarOphthalmology, Glaucoma, University of California Los Angeles, Los Angeles, CA, USA.
Esteban MoralesOphthalmology, Glaucoma, University of California Los Angeles, Los Angeles, CA, USA.
Peter TranOphthalmology, Glaucoma, University of California Los Angeles, Los Angeles, CA, USA.
Janet LeeOphthalmology, Retina, University of California Los Angeles, Los Angeles, CA, USA.
Jean-Pierre HubschmanOphthalmology, Retina, University of California Los Angeles, Los Angeles, CA, USA.
Kouros Nouri-MahdaviOphthalmology, Glaucoma, University of California Los Angeles, Los Angeles, CA, USA.
Joseph CaprioliOphthalmology, Glaucoma, University of California Los Angeles, Los Angeles, CA, USA Caprioli@jsei.ucla.edu.ORCID 0000-0002-2383-7263
University of California, Los Angeles · US

Funding

Detection of Disease Progression in Advanced GlaucomaR01EY029792 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI NOURI-MAHDAVI, KOUROS · 2020 to 2024
$1.9M
Trigeminal Afferents Regulation of Apical Periodontitis DevelopmentR01DE027929 · NIDCR · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI DIOGENES, ANIBAL · 2018 to 2022
$1.8M
NEI NIH HHS R01 EY029792NIDCR NIH HHS R01 DE027929
6 · The paper itself

Abstract

BACKGROUND/

aimsTo identify clinical characteristics and factors associated with microcystic macular edema (MME) in patients with primary open-angle glaucoma (POAG).

methodsWe included 315 POAG eyes between 2010 and 2019 with good-quality macular volume scans that had reliable visual fields (VF) available within 6 months in this observational retrospective cohort study. Eyes with retinal pathologies except for epiretinal membrane (ERM) were excluded. The inner nuclear layer was qualitatively assessed for the presence of MME. Global mean deviation (MD) and Visual Field Index (VFI) decay rates, superior and inferior MD rates and pointwise total deviation rates of change were estimated with linear regression. Logistic regression was performed to identify baseline factors associated with the presence of MME and to determine whether MME is associated with progressive VF loss.

results25 out of 315 eyes (7.9%) demonstrated MME. The average (±SD) age and MD in eyes with and without MME was 57.2 (±8.7) versus 62.0 (±9.9) years (p=0.02) and -9.8 (±5.7) versus -4.9 (±5.3) dB (p<0.001), respectively. Worse global MD at baseline (p=0.001) and younger age (p=0.02) were associated with presence of MME. ERM was not associated with the presence of MME (p=0.84) in this cohort. MME was not associated with MD and VFI decay rates (p>0.49).

conclusionsMore severe glaucoma and younger age were associated with MME. MME was not associated with faster global VF decay in this cohort. MME may confound monitoring of glaucoma with full macular thickness.

Indexed as

Epiretinal MembraneGlaucomaGlaucoma, Open-AngleMacular EdemaHumansIntraocular PressureRetinal Ganglion CellsRetrospective StudiesRisk FactorsTomography, Optical Coherenceglaucomaimagingmacula

Identifiers

PMID34740886
PMCPMC9068828
OpenAlexW3208627229

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.