Evidence map›Paper›PMID 34740717›Full record

SynthesisInternational journal of cardiology2022

Worldwide differences of hospitalization for ST-segment elevation myocardial infarction during COVID-19: A systematic review and meta-analysis.

Francesco Sofi, Monica Dinu, GianPaolo Reboldi, Fabrizio Stracci, Roberto F E Pedretti, Serafina Valente, GianFranco Gensini, C Michael Gibson, Giuseppe Ambrosio

Open access · bronzeAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in International journal of cardiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Postpandemic Cardiac Mortality Rates.JAMA network open · 2025
    Article
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  6. Review
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  11. Review
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  15. Article
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  18. The impact of the coronavirus pandemic on patients hospitalized due to acute coronary syndrome.Postepy w kardiologii interwencyjnej = Advances in interventional cardiology · 2023
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Francesco SofiDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Monica DinuDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
GianPaolo ReboldiDepartment of Medicine, University of Perugia School of Medicine, Perugia, Italy; Center for Clinical and Translational Research-CERICLET, University of Perugia School of Medicine, Perugia, Italy.
Fabrizio StracciDepartment of Medicine, University of Perugia School of Medicine, Perugia, Italy.
Roberto F E PedrettiIRCCS MultiMedica, Milan, Italy.
Serafina ValenteCardiology, Siena University Hospital, Siena, Italy.
GianFranco GensiniIRCCS MultiMedica, Milan, Italy.
C Michael GibsonBaim Institute for Clinical Research, Harvard Medical School, Boston, MS, United States of America.
Giuseppe AmbrosioCenter for Clinical and Translational Research-CERICLET, University of Perugia School of Medicine, Perugia, Italy; Division of Cardiology, University of Perugia School of Medicine, Perugia, Italy. Electronic address: giuseppe.ambrosio@unipg.it.
University of Perugia · ITMultiMedica · ITUniversity of Florence · ITBaim Institute for Clinical Research · USUniversity of Siena · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDiscrepant data were reported about hospital admissions for ST-segment elevation myocardial infarction (STEMI) during COVID-19 pandemic. We reviewed studies reporting STEMI hospitalizations during COVID-19 pandemic, investigating whether differences in COVID-19 epidemiology or public health-related factors could explain discrepant findings in different countries.

methodsSearch through MedLine, Embase, Scopus, Web-of-Science, Cochrane Register of Controlled Trials, of studies comparing STEMI admissions during COVID-19 pandemic with a reference period, without language restrictions, as registered in PROSPERO International Prospective Register of Systematic Reviews. Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines were followed. Data independently extracted by multiple investigators were pooled using a random-effects model. Health-related metrics were from publicly-available sources.

resultsWe included 79 articles (111,557 STEMI cases, from 57 countries). During peak COVID-19 pandemic, overall incidence rate-ratio (IRR) of STEMI hospitalizations over reference period decreased (0.80; 95% CI 0.76-0.84; p < 0.05). Although wide variations and significant heterogeneity were detected among studies (I

conclusionsDuring COVID-19 pandemic hospitalization for STEMI significantly decreased, although to a smaller extent than initially reported. Large variability emerged across countries, unrelated to COVID-related epidemiology or social containment measures. Disparities in healthcare organization likely contributed, indicating that proper organization of emergency medicine should be preserved during pandemics.

Indexed as

COVID-19Percutaneous Coronary InterventionST Elevation Myocardial InfarctionHospitalizationHumansPandemicsSARS-CoV-2Acute coronary syndromesCOVID-19Healthcare organizationMyocardial infarctionSars-Cov-2STEMI

Identifiers

PMID34740717
PMCPMC8561779
OpenAlexW3208459935

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.