Evidence map›Paper›PMID 34739908›Full record

SynthesisDiabetes & metabolic syndrome

Vitamin C and COVID-19 treatment: A systematic review and meta-analysis of randomized controlled trials.

Dimple Rawat, Avishek Roy, Souvik Maitra, Arti Gulati, Puneet Khanna, Dalim Kumar Baidya

Open access · greenAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Diabetes & metabolic syndrome. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 9 pooled it
9.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 9 syntheses or guidelines pooled it, 82 citations in OpenAlex.

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  7. Janus kinase inhibitors for the treatment of COVID-19.The Cochrane database of systematic reviews · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Dimple RawatClinical Epidemiology Unit, All India Institute of Medical Sciences, New Delhi, India. Electronic address: rawat.dimple96@gmail.com.
Avishek RoyDepartment of Anaesthesiology, Pain Medicine and Critical Care, All India Institute of Medical Sciences, New Delhi, India. Electronic address: roy.avishek1992@gmail.com.
Souvik MaitraDepartment of Anaesthesiology, Pain Medicine and Critical Care, All India Institute of Medical Sciences, New Delhi, India. Electronic address: souvikmaitra@live.com.
Arti GulatiClinical Epidemiology Unit, All India Institute of Medical Sciences, New Delhi, India. Electronic address: gulatiarti@yahoo.co.uk.
Puneet KhannaDepartment of Anaesthesiology, Pain Medicine and Critical Care, All India Institute of Medical Sciences, New Delhi, India. Electronic address: k.punit@yahoo.com.
Dalim Kumar BaidyaDepartment of Anaesthesiology, Pain Medicine and Critical Care, All India Institute of Medical Sciences, New Delhi, India. Electronic address: dalimkumar.ab8@gmail.com.
All India Institute of Medical Sciences · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsVitamin C has been used as an anti-oxidant in various diseases including viral illnesses like coronavirus disease (COVID-19).

methodsMeta-analysis of randomized controlled trials (RCT) investigating the role of vitamin C supplementation in COVID-19 was carried out.

resultsTotal 6 RCTs including n = 572 patients were included. Vitamin C treatment didn't reduce mortality (RR 0.73, 95% CI 0.42 to 1.27; I

conclusionNo significant benefit noted with vitamin C administration in COVID-19. Well-designed RCTs with standardized control group needed on this aspect.

Indexed as

COVID-19 Drug TreatmentAntioxidantsAscorbic AcidCOVID-19Dietary SupplementsHumansLength of StayRandomized Controlled Trials as TopicAntioxidantsAscorbic AcidAscorbic acidCoronavirusCOVID 19COVID penumonial-ascorbateSARS-CoV-2Vitamin C

Identifiers

PMID34739908
PMCPMC8552785
OpenAlexW3211017908

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.