Evidence map›Paper›PMID 34739868›Full record

SynthesisThe American journal of emergency medicine2022

COVID-19 associated myocarditis: A systematic review.

William Haussner, Antonio P DeRosa, Danielle Haussner, Jacqueline Tran, Jane Torres-Lavoro, Jonathan Kamler, Kaushal Shah

Open access · greenAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The American journal of emergency medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 4 pooled it
10.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 4 syntheses or guidelines pooled it, 74 citations in OpenAlex.

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  3. Multisystem Inflammatory Syndrome in Adults: Case Finding Through Systematic Review of Electronic Medical Records.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

William HaussnerNew York Presbyterian-Weill Cornell Medicine, 525 East 68(th) Street, New York, NY 10065, USA. Electronic address: wkh9002@nyp.org.
Antonio P DeRosaSamuel J. Wood Library & C.V. Starr Biomedical Information Center, 1305 York Ave., New York, NY 10065, USA. Electronic address: apd2004@med.cornell.edu.
Danielle HaussnerNew York Presbyterian-Weill Cornell Medicine, 525 East 68(th) Street, New York, NY 10065, USA. Electronic address: dbm9003@nyp.org.
Jacqueline TranWeill Cornell Medicine, Weill Cornell Medical College, 1300 York Ave., New York, NY 10065, USA. Electronic address: Jtl4001@med.cornell.edu.
Jane Torres-LavoroWeill Cornell Medicine, Emergency Medicine, 525 East 68(th) Street, Box 179, New York, NY 10065, USA. Electronic address: Jat2033@med.cornell.edu.
Jonathan KamlerNew York Presbyterian-Weill Cornell Medicine, 525 East 68(th) Street, New York, NY 10065, USA. Electronic address: Jjk7003@nyp.org.
Kaushal ShahNew York Presbyterian-Weill Cornell Medicine, 525 East 68(th) Street, New York, NY 10065, USA. Electronic address: Kas3002@med.cornell.edu.
Cornell University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMost COVID-19 infections result in a viral syndrome characterized by fever, cough, shortness of breath, and myalgias. A small but significant proportion of patients develop severe COVID-19 resulting in respiratory failure. Many of these patients also develop multi-organ dysfunction as a byproduct of their critical illness. Although heart failure can be a part of this, there also appears to be a subset of patients who have primary cardiac collapse from COVID-19.

objectiveConduct a systematic review of COVID-19-associated myocarditis, including clinical presentation, risk factors, and prognosis. DISCUSSION: Our review demonstrates two distinct etiologies of primary acute heart failure in surprisingly equal incidence in patients with COVID-19: viral myocarditis and Takotsubo cardiomyopathy. COVID myocarditis, Takotsubo cardiomyopathy, and severe COVID-19 can be clinically indistinguishable. All can present with dyspnea and evidence of cardiac injury, although in myocarditis and Takotsubo this is due to primary cardiac dysfunction as compared to respiratory failure in severe COVID-19.

conclusionCOVID-19-associated myocarditis differs from COVID-19 respiratory failure by an early shock state. However, not all heart failure from COVID-19 is from direct viral infection; some patient's develop takotsubo cardiomyopathy. Regardless of etiology, steroids may be a beneficial treatment, similar to other critically ill COVID-19 patients. Evidence of cardiac injury in the form of ECG changes or elevated troponin in patients with COVID-19 should prompt providers to consider concurrent myocarditis.

Indexed as

COVID-19DyspneaHeart FailureHumansMyocarditisRespiratory InsufficiencyRisk FactorsTakotsubo CardiomyopathyCOVID-19Heart failureMyocarditisPrimary cardiac collapseSystematic reviewTakotsubo cardiomyopathy

Identifiers

PMID34739868
PMCPMC8531234
OpenAlexW3209543587

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.