ArticleAmerican journal of human genetics2021
Bonsai: An efficient method for inferring large human pedigrees from genotype data.
Article in American journal of human genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- The genetic legacy of the 17th-century colonial capital of St. Mary's City.Current biology : CB · 2026Article
- Fault-tolerant pedigree reconstruction from pairwise kinship relations.Bioinformatics (Oxford, England) · 2026Article
- A novel method for across-chromosome phasing without relative data.Bioinformatics (Oxford, England) · 2026Article
- COMPADRE: Combined pedigree-aware distant relatedness estimation for improved pedigree reconstruction.American journal of human genetics · 2025Article
- Article
- CORRECTING MODEL MISSPECIFICATION IN RELATIONSHIP ESTIMATES.bioRxiv : the preprint server for biology · 2024Article
- Reconstructing parent genomes using siblings and other relatives.bioRxiv : the preprint server for biology · 2024Article
- Supporting the use of genetic genealogy in restoring family narratives following the transatlantic slave trade.American anthropologist · 2024Article
- Ethical considerations when co-analyzing ancient DNA and data from private genetic databases.American journal of human genetics · 2023Review
- The genetic legacy of African Americans from Catoctin Furnace.Science (New York, N.Y.) · 2023Article
- Addressing the feasibility of people of African descent finding living African relatives using direct-to-consumer genetic testing.American journal of biological anthropology · 2023Article
- Evaluating the utility of identity-by-descent segment numbers for relatedness inference via information theory and classification.G3 (Bethesda, Md.) · 2022Article
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5 authors.
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Abstract
Pedigree inference from genotype data is a challenging problem, particularly when pedigrees are sparsely sampled and individuals may be distantly related to their closest genotyped relatives. We present a method that infers small pedigrees of close relatives and then assembles them into larger pedigrees. To assemble large pedigrees, we introduce several formulas and tools including a likelihood for the degree separating two small pedigrees, a generalization of the fast DRUID point estimate of the degree separating two pedigrees, a method for detecting individuals who share background identity-by-descent (IBD) that does not reflect recent common ancestry, and a method for identifying the ancestral branches through which distant relatives are connected. Our method also takes several approaches that help to improve the accuracy and efficiency of pedigree inference. In particular, we incorporate age information directly into the likelihood rather than using ages only for consistency checks and we employ a heuristic branch-and-bound-like approach to more efficiently explore the space of possible pedigrees. Together, these approaches make it possible to construct large pedigrees that are challenging or intractable for current inference methods.
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