Evidence map›Paper›PMID 34739819›Full record

ArticleCurrent biology : CB2021

Rho and F-actin self-organize within an artificial cell cortex.

Jennifer Landino, Marcin Leda, Ani Michaud, Zachary T Swider, Mariah Prom, Christine M Field, William M Bement, Anthony G Vecchiarelli, Andrew B Goryachev, Ann L Miller

Open access · greenAbstract read
In one paragraph

Article in Current biology : CB, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Article
  3. Single-cell chiral symmetry breaking under confinement.bioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Patterning of the cell cortex by Rho GTPases.Nature reviews. Molecular cell biology · 2024
    Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Jennifer LandinoDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI, USA. Electronic address: landinoj@umich.edu.
Marcin LedaCentre for Synthetic and Systems Biology, University of Edinburgh, Edinburgh, UK.
Ani MichaudCellular and Molecular Biology Graduate Program, University of Wisconsin-Madison, Madison, WI, USA; Center for Quantitative Cell Imaging, University of Wisconsin-Madison, Madison, WI, USA.
Zachary T SwiderCellular and Molecular Biology Graduate Program, University of Wisconsin-Madison, Madison, WI, USA; Center for Quantitative Cell Imaging, University of Wisconsin-Madison, Madison, WI, USA.
Mariah PromCenter for Quantitative Cell Imaging, University of Wisconsin-Madison, Madison, WI, USA.
Christine M FieldDepartment of Systems Biology, Harvard Medical School, Boston, MA, USA.
William M BementCellular and Molecular Biology Graduate Program, University of Wisconsin-Madison, Madison, WI, USA; Center for Quantitative Cell Imaging, University of Wisconsin-Madison, Madison, WI, USA; Department of Integrative Biology, University of Wisconsin-Madison, Madison, WI, USA.
Anthony G VecchiarelliDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.
Andrew B GoryachevCentre for Synthetic and Systems Biology, University of Edinburgh, Edinburgh, UK.
Ann L MillerDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI, USA. Electronic address: annlm@umich.edu.
University of Michigan · USUniversity of Edinburgh · GBUniversity of Wisconsin–Madison · USUniversity of Wisconsin System · USHarvard University · US

Funding

Cell and Chemical Biology of MicrotubulesR35GM131753 · NIGMS · HARVARD MEDICAL SCHOOL · PI Timothy J Mitchison · 2019 to 2026
$6.4M
Biotechnology and Biological Sciences Research Council BB/P006507Biotechnology and Biological Sciences Research Council BB/P01190XNIGMS NIH HHS R35 GM131753
6 · The paper itself

Abstract

The cell cortex, comprised of the plasma membrane and underlying cytoskeleton, undergoes dynamic reorganizations during a variety of essential biological processes including cell adhesion, cell migration, and cell division.

Indexed as

ActinsArtificial CellsActin CytoskeletonAnimalsCytokinesisrho GTP-Binding ProteinsSpindle ApparatusActinsrho GTP-Binding Proteinscell cortexexcitabilityF-actinoscillationsReconstitutionRho GTPasesself-organizationsupported lipid bilayerwavesXenopus extract

Identifiers

PMID34739819
PMCPMC8692417
OpenAlexW3202237276

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.