Evidence map›Paper›PMID 34739688›Full record

ArticleMolecular biology reports2022

Galactose specific lectins from prostate tissue with different pathologies: biochemical and cellular studies.

Elene Davitashvili, George Burjanadze, Marine Koshoridze, Nana Koshoridze, Tamar Tsertsvadze, Nunu Mitskevich, Omar Tsintsadze, Guram Karazanashvili, Revaz Solomonia

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Article in Molecular biology reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed, 1 citations in OpenAlex.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Elene DavitashviliDepartment of Biology, Chair of Biochemistry, Faculty of Exact and Natural Sciences, Ivane Javakhishvili Tbilisi State University, Tbilisi, Georgia. elene.davitashvili@tsu.ge.ORCID http://orcid.org/0000-0002-8016-0041
George BurjanadzeDepartment of Biology, Chair of Biochemistry, Faculty of Exact and Natural Sciences, Ivane Javakhishvili Tbilisi State University, Tbilisi, Georgia.ORCID http://orcid.org/0000-0002-5404-0644
Marine KoshoridzeDepartment of Biology, Chair of Biochemistry, Faculty of Exact and Natural Sciences, Ivane Javakhishvili Tbilisi State University, Tbilisi, Georgia.ORCID http://orcid.org/0000-0002-8988-6893
Nana KoshoridzeDepartment of Biology, Chair of Biochemistry, Faculty of Exact and Natural Sciences, Ivane Javakhishvili Tbilisi State University, Tbilisi, Georgia.ORCID http://orcid.org/0000-0001-7324-1495
Tamar TsertsvadzeDepartment of Biology Chair of Immunology and Microbiology, Faculty of Exact and Natural Sciences, Ivane Javakhishvili Tbilisi State University, Tbilisi, Georgia.ORCID http://orcid.org/0000-0003-2750-0454
Nunu MitskevichDepartment of Biology Chair of Immunology and Microbiology, Faculty of Exact and Natural Sciences, Ivane Javakhishvili Tbilisi State University, Tbilisi, Georgia.
Omar TsintsadzeA. Tsulukidze Urology National Center, Pathomorphology Laboratory 1st Clinical Hospital, Tbilisi, Georgia.ORCID http://orcid.org/0000-0003-1125-8501
Guram KarazanashviliClinic of SJC "Modern Medical Technologies", Tbilisi, Georgia.ORCID http://orcid.org/0000-0002-9153-5785
Revaz SolomoniaInstitute of Chemical Biology, Ilia State University, Tbilisi, Georgia.ORCID http://orcid.org/0000-0003-4798-6762
Tbilisi State University · GEIlia State University · GEMedical Technologies (Czechia) · CZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGalectins-galactose-specific lectins are involved in various types of cell activities, including apoptosis, cell cycle regulation, inflammation and cell transformation. Galectins are implicated in prostate malignat transformation. It is not known yet if prostate glands with different grade of pathologies are expressing different galectins and if these galectins express different effects on the cell viability.

methodsCytosolic galactose-spesific lectin fractions from prostate tissue with different diagnosis were purified by affinity chromatography and analyzed by electrophoresis in polyacrylamide gel electrophoresis with sodium dodecyl sulphate. The lectin effects in a source-dependent maner were studied on cell viability on peripheral lymphocytes by MTT reduction method and on apoptosis by flow cytometry method.

resultsAffinity purified galactose-specific lectins fractions from normal and pathological tissue samples are characterized with different protein composition and they express different effects on cell viability and apoptosis.

conclusionThe effects of cytosolic galactose-specific lectins depend on the source of lectin fraction (glandular tissue disease). We suppose that the released cytosolic galectins from prostatic high grade intraepithelial neoplasia and adenocarcinoma tissue could suppress the immune status of the host patients.

Indexed as

ApoptosisBiomarkersCell FractionationDisease SusceptibilityGalectinsGene Expression RegulationHemagglutinationHumansMaleProstateBiomarkersGalectinsApoptosisCells survival viabilityGland diseasesProstate galactose-specific lectins

Identifiers

PMID34739688
OpenAlexW3208845725

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