Evidence map›Paper›PMID 34739617›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2022

First report of a homozygous mutation on exon 24 of the NOTCH3 gene in a paucisymptomatic CADASIL elderly patient.

Michele Ragno, Luigi Pianese, Sara Tiberi, Gabriella Cacchiò, Cristina Paci, Luigi Trojano

Abstract readCase ReportsLetter
PubMed Publisher
In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. CADASIL orFrontiers in neurology · 2025
    Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Michele RagnoPianeta Salute, Viale Assisi, 88, 63084 Villa Pigna, Ascoli Piceno, Italy.
Luigi PianeseU.O.C. Patologia Clinica, ASUR Marche Area Vasta 5, Ascoli Piceno, Italy.
Sara TiberiDivision of Neurology, Ospedale Madonna del Soccorso, ASUR Marche, San Benedetto del Tronto-Ascoli Piceno, Italy.
Gabriella CacchiòDivision of Neurology, Ospedale Madonna del Soccorso, ASUR Marche, San Benedetto del Tronto-Ascoli Piceno, Italy.
Cristina PaciDivision of Neurology, Ospedale Madonna del Soccorso, ASUR Marche, San Benedetto del Tronto-Ascoli Piceno, Italy.
Luigi TrojanoDepartment of Psychology, University of Campania 'Luigi Vanvitelli', Viale Ellittico 31, 81100, Caserta, Italy. luigi.trojano@unicampania.it.ORCID http://orcid.org/0000-0002-0328-9642
University of Campania "Luigi Vanvitelli" · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

CADASILAgedExonsFemaleHomozygoteHumansMagnetic Resonance ImagingMutationMutation, MissensePedigreeReceptor, Notch3Receptors, NotchNOTCH3 protein, humanReceptor, Notch3Receptors, Notch

Identifiers

PMID34739617
OpenAlexW3208477360

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.