Evidence map›Paper›PMID 34739475›Full record

ArticleActa bio-medica : Atenei Parmensis2021

HMGB1-antagonism exerted by glycyrrhizin could be fruitful against COVID-19.

Giorgio Ciprandi, Luisa Maria Bellussi, Valerio Damiani, Desiderio Passali

Open access · greenAbstract read
In one paragraph

Article in Acta bio-medica : Atenei Parmensis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 83% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 3 countries.

Giorgio CiprandiConsultant Allergist, Casa di Cura Villa Montallegro, Genoa, Italy. gio.cip@libero.it.
Luisa Maria BellussiInternational Federation ORL Societies (IFOS) Executive Board members Rome Italy. lm.bellussi@virgilio.it.
Valerio DamianiMedical Department, DMG Italia, Rome, Italy.. valerio.damiani@dmgit.com.
Desiderio PassaliInternational Federation ORL Societies (IFOS) Executive Board members Rome Italy. d.passali@virgilio.it.
Casa di Cura Villa Garda · ITInternational Federation of Red Cross and Red Crescent Societies · CHInternational Union of Pure and Applied Chemistry · USOspedale Valduce · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The COVID-19 pandemic era is causing a relevant issue for the health. There is no specific drug able to antagonize the SARS-CoV-2 infection. As a consequence, there is growing interest about potential molecules able to contrast infection. In this regard, HMGB, an alarmin, may play a relevant role in pathogenic mechanisms induced by SARS-CoV-2.  As HMGB1 is antagonized by glycyrrhizin, this substance could be potentially useful as ancillary treatment in COVID-19.

Indexed as

COVID-19HMGB1 ProteinGlycyrrhizic AcidHumansPandemicsSARS-CoV-2Glycyrrhizic AcidHMGB1 Protein

Identifiers

PMID34739475
PMCPMC8851008
OpenAlexW3209845994

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.