ArticleAmerican journal of respiratory and critical care medicine2022
Development of a Blood-based Transcriptional Risk Score for Chronic Obstructive Pulmonary Disease.
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In one paragraph
Article in American journal of respiratory and critical care medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
5.7field-weighted citation impact, top 3% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Gene expression associations with body mass index in the Multi-Ethnic Study of Atherosclerosis.International journal of obesity (2005) · 2023Pooled it
- Development of a peripheral blood transcriptomic gene signature to predict bronchopulmonary dysplasia.American journal of physiology. Lung cellular and molecular physiology · 2023Trial
- Sex-related transcriptomic differences in idiopathic pulmonary fibrosis.American journal of respiratory and critical care medicine · 2026Article
- Unfolding Immune Dysregulation in COPD: Identification of a Three-Gene Signature and Functional Validation ofInternational journal of molecular sciences · 2026Article
- Shared molecular signatures between atrial fibrillation and chronic obstructive pulmonary disease: an integrated bioinformatic analysis with experimental validation.BMC medical genomics · 2026Article
- Integrative multi-omic analyses identify major axes of heterogeneity in chronic obstructive pulmonary disease and uncover their molecular contributors.medRxiv : the preprint server for health sciences · 2026Article
- Post-COPD: Can Emphysema Be Repaired?American journal of respiratory and critical care medicine · 2025Article
- Assessing inflammatory protein biomarkers in COPD subjects with and without alpha-1 antitrypsin deficiency.Respiratory research · 2025Article
- Article
- Omic Risk Scores are Associated with COPD-related Traits Across Three Cohorts.medRxiv : the preprint server for health sciences · 2025Article
- Piece of Cake: Slicing through the Complex Layers of Chronic Obstructive Pulmonary Disease with Lung Tissue Network Analysis.American journal of respiratory and critical care medicine · 2024Article
- PARK2 as a susceptibility factor for nontuberculous mycobacterial pulmonary disease.Respiratory research · 2024Article
- Leveraging blood-based transcriptomics to detect acute cellular rejection in lung transplant.JHLT open · 2024Article
- Plasmonic Alloys Enhanced Metabolic Fingerprints for the Diagnosis of COPD and Exacerbations.ACS central science · 2024Article
- Whole Blood-based Transcriptional Risk Score for Nonobese Type 2 Diabetes Predicts Dynamic Changes in Glucose Metabolism.The Journal of clinical endocrinology and metabolism · 2023Article
- Does Chronic Obstructive Pulmonary Disease Originate from Different Cell Types?American journal of respiratory cell and molecular biology · 2023Article
- Deep Learning Integration of Chest Computed Tomography Imaging and Gene Expression Identifies Novel Aspects of COPD.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2023Article
- Understanding COPD Etiology, Pathophysiology, and Definition.Respiratory care · 2023Article
- Proteogenomic analysis of human cerebrospinal fluid identifies neurologically relevant regulation and informs causal proteins for Alzheimer's disease.Research square · 2023Article
- Combining single-cell RNA sequencing of peripheral blood mononuclear cells and exosomal transcriptome to reveal the cellular and genetic profiles in COPD.Respiratory research · 2022Article
Corrections and comments
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Authors and funding
15 authors at 5 institutions in 2 countries.
Matthew MollChanning Division of Network Medicine.ORCID 0000-0002-0683-0975
Adel BoueizChanning Division of Network Medicine.
Auyon J GhoshChanning Division of Network Medicine.
Aabida SaferaliChanning Division of Network Medicine.
Sool LeeChanning Division of Network Medicine.
Zhonghui XuChanning Division of Network Medicine.
Jeong H YunChanning Division of Network Medicine.ORCID 0000-0002-4361-8295
Brian D HobbsChanning Division of Network Medicine.ORCID 0000-0001-9564-0745
Craig P HershChanning Division of Network Medicine.ORCID 0000-0002-1342-4334
Don D SinCentre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, British Columbia, Canada.
Ruth Tal-SingerCOPD Foundation, Washington, DC.
Edwin K SilvermanChanning Division of Network Medicine.
Michael H ChoChanning Division of Network Medicine.
Peter J CastaldiChanning Division of Network Medicine.
HAPIN Investigators
Pulmonary and Critical Care Associates · USBrigham and Women's Hospital · USCOPD Foundation · USUniversity of British Columbia · CAUniversity of North Carolina at Chapel Hill · US
Funding
Genetic Epidemiology of COPDU01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2007 to 2021
$56.9MMetabolomic signatures of empysema and COPD progression in the COPDGene cohortR01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2012 to 2016
$31.1MVector Core-Core 2P30DK054759 · NIDDK · UNIVERSITY OF IOWA · PI Alejandro Antonio Pezzulo · 1998 to 2026
$30.5MRespiratory Computational Discovery CoreP01HL114501 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI SILVERMAN, EDWIN K · 2013 to 2025
$24.9MGenetic Epidemiology of COPDU01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2007 to 2021
$20.7M(2 of 2) Genetic Epidemiology of COPDR01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2012 to 2016
$18.9MSYSTEMS APPROACHES TO THE EPIDEMIOLOGY, GENETICS AND GENOMICS OF LUNG DISEASEST32HL007427 · NHLBI · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI DAWN L DEMEO, Edwin K Silverman · 1985 to 2026
$13.6MSystems Biology of Airway DiseaseP01HL132825 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI WEISS, SCOTT T · 2016 to 2020
$12.6MGenetic and Genomic Characterization of the Occurrence and Progression of Interstitial Lung AbnormalitiesR01HL135142 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MICHAEL H. CHO, GARY MATTHEW HUNNINGHAKE · 2017 to 2026
$7.7MCOPD Susceptibility, Heterogeneity, and Progression: Proteomics and GeneticsR01HL133135 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MORITZ, ROBERT L, SILVERMAN, EDWIN K · 2017 to 2025
$7.2MUsing Integrative Genomics To Identify and Characterize Emphysema-Associated eQTLR01HL124233 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI CASTALDI, PETER · 2014 to 2024
$7.1MGenetic and Functional Dissection of a Cluster of COPD GWAS Signals on Chromosome 4qR01HL147148 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI CHO, MICHAEL H., SILVERMAN, EDWIN K · 2019 to 2022
$3.5MNHLBI NIH HHS K01 HL157613NHLBI NIH HHS K08 HL136928NHLBI NIH HHS K08HL136928NHLBI NIH HHS K08 HL141601NHLBI NIH HHS K08HL141601NHLBI NIH HHS K08 HL146972NHLBI NIH HHS K08HL146972NHLBI NIH HHS P01 HL114501NHLBI NIH HHS P01 HL132825NHLBI NIH HHS R01 HL089856NHLBI NIH HHS R01 HL089897NHLBI NIH HHS R01 HL124233NHLBI NIH HHS R01HL124233NHLBI NIH HHS R01 HL125583NHLBI NIH HHS R01HL125583NHLBI NIH HHS R01 HL130512NHLBI NIH HHS R01HL130512NHLBI NIH HHS R01 HL133135NHLBI NIH HHS R01HL133135NHLBI NIH HHS R01 HL135142NHLBI NIH HHS R01HL135142NHLBI NIH HHS R01 HL137927NHLBI NIH HHS R01HL137927NHLBI NIH HHS R01 HL147148NHLBI NIH HHS R01 HL147326NHLBI NIH HHS R01HL147326NHLBI NIH HHS T32 HL007427NHLBI NIH HHS T32HL007427NHLBI NIH HHS U01 HL089856NHLBI NIH HHS U01 HL089897NHLBI NIH HHS U01HL147148NIDDK NIH HHS P30 DK054759NIGMS NIH HHS T32 GM135123
Abstract
PubMed holds no abstract for this paper.
Indexed as
Disease ProgressionAgedBiomarkersFemaleGene Expression RegulationGenetic Predisposition to DiseaseHumansMaleMiddle AgedMultifactorial InheritanceOdds RatioPhenotypePredictive Value of TestsProspective StudiesPulmonary Disease, Chronic ObstructiveRisk AssessmentBiomarkersTranscription FactorsCOPDFEV1 declinepolygenic risk scorerisk predictiontranscriptomic
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.