Evidence map›Paper›PMID 34739318›Full record

ArticleScience advances2021

DNA methylation at a nutritionally sensitive region of the

Toby Candler, Noah J Kessler, Chathura J Gunasekara, Kate A Ward, Philip James, Eleonora Laritsky, Maria S Baker, Roger Dyer, Rajavel Elango, David Jeffries and 5 more

Abstract read
In one paragraph

Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
  3. The ecological function of thyroid hormones.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024
    Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Toby CandlerMRC Unit The Gambia at the London School of Hygiene and Tropical Medicine, London, UK.ORCID 0000-0002-4587-8744
Noah J KesslerDepartment of Genetics, University of Cambridge, Cambridge, UK.ORCID 0000-0002-2740-6663
Chathura J GunasekaraUSDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Kate A WardMRC Unit The Gambia at the London School of Hygiene and Tropical Medicine, London, UK.
Philip JamesDepartment of Population Health, London School of Hygiene and Tropical Medicine, London, UK.ORCID 0000-0001-5448-8193
Eleonora LaritskyUSDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Maria S BakerUSDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Roger DyerBritish Columbia Children's Hospital Research Institute, Vancouver, BC, Canada.ORCID 0000-0003-2009-1563
Rajavel ElangoBritish Columbia Children's Hospital Research Institute, Vancouver, BC, Canada.ORCID 0000-0002-9380-1725
David JeffriesMRC Unit The Gambia at the London School of Hygiene and Tropical Medicine, London, UK.ORCID 0000-0001-7471-1364
Robert A WaterlandUSDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0002-7401-3408
Sophie E MooreMRC Unit The Gambia at the London School of Hygiene and Tropical Medicine, London, UK.ORCID 0000-0003-1650-3238
Marian LudgateThyroid Research Group, School of Medicine, Cardiff University, Cardiff, UK.ORCID 0000-0002-7436-0821
Andrew M PrenticeMRC Unit The Gambia at the London School of Hygiene and Tropical Medicine, London, UK.ORCID 0000-0001-5389-451X
Matt J SilverMRC Unit The Gambia at the London School of Hygiene and Tropical Medicine, London, UK.ORCID 0000-0002-3852-9677

Funding

Translational Research Support CoreP30ES030285 · NIEHS · BAYLOR COLLEGE OF MEDICINE · PI Cheryl L. Walker · 2019 to 2026
$14.7M
Medical Research Council MC_EX_MR/M01424X/1Medical Research Council MC_PC_MR/R020183/1Medical Research Council MC_U123292700Medical Research Council MC_U123292701Medical Research Council MC_UP_1005/1Medical Research Council MC_UU_00026/3Medical Research Council MR/P012019/1Medical Research Council MR/S006516/1Medical Research Council MR/T032863/1NIEHS NIH HHS P30 ES030285
6 · The paper itself

Abstract

PAX8 is a key thyroid transcription factor implicated in thyroid gland differentiation and function, and

Identifiers

PMID34739318
PMCPMC8570597

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.