ArticleScience advances2021
Networks of habenula-projecting cortical neurons regulate cocaine seeking.
Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Response Flexibility: The Role of the Lateral Habenula.Frontiers in behavioral neuroscience · 2022Pooled it
- Neuroanatomical and behavioral characterization of corticotropin-releasing factor-expressing lateral Habenula neurons in mice.Communications biology · 2026Article
- Neuroanatomical and behavioral characterization of corticotropin releasing factor-expressing lateral Habenula neurons in mice.bioRxiv : the preprint server for biology · 2026Article
- A pathway from the anterior cingulate cortex to the lateral habenula controls chronic pain-induced depression in male mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Long-range cortical GABA neurons oppose binge drinking.Nature neuroscience · 2025Article
- Prolactin-Releasing Peptide System as a Potential Mechanism of Stress Coping: Studies in Male Rats.International journal of molecular sciences · 2025Article
- Massive multiplexing of spatially resolved single neuron projections with axonal BARseq.Nature communications · 2024Article
- The lateral habenula integrates age and experience to promote social transitions in developing rats.Cell reports · 2024Article
- Elevated dorsal medial prefrontal cortex to lateral habenula pathway activity mediates chronic stress-induced depressive and anxiety-like behaviors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- A discrete subpopulation of PFC-LHb neurons govern cocaine place preference.Translational psychiatry · 2024Article
- A master regulator of opioid reward in the ventral prefrontal cortex.Science (New York, N.Y.) · 2024Article
- Glutamatergic neurons in ventral pallidum modulate heroin addiction via epithalamic innervation in rats.Acta pharmacologica Sinica · 2024Article
- Input-output specific orchestration of aversive valence in lateral habenula during stress dynamics.Journal of Zhejiang University. Science. B · 2024Review
- Rabies virus-based barcoded neuroanatomy resolved by single-cell RNA and in situ sequencing.eLife · 2024Article
- The lateral habenula integrates age and experience to promote social transitions in developing rats.bioRxiv : the preprint server for biology · 2024Article
- Rabies virus-based barcoded neuroanatomy resolved by single-cell RNA andbioRxiv : the preprint server for biology · 2023Article
- Involvement of cortical input to the rostromedial tegmental nucleus in aversion to foot shock.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Brain-Wide Projections and Differential Encoding of Prefrontal Neuronal Classes Underlying Learned and Innate Threat Avoidance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Massive Multiplexing of Spatially Resolved Single Neuron Projections with Axonal BARseq.bioRxiv : the preprint server for biology · 2023Article
- Prefrontal-habenular microstructural impairments in human cocaine and heroin addiction.Neuron · 2022Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
How neurons in the medial prefrontal cortex broadcast stress-relevant information to subcortical brain sites to regulate cocaine relapse remains unclear. The lateral habenula (LHb) serves as a “hub” to filter and propagate stress- and aversion-relevant information in the brain. Here, we show that chemogenetic inhibition of cortical inputs to LHb attenuates relapse-like reinstatement of extinguished cocaine seeking in mice. Using an RNA sequencing–based brain mapping procedure with single-cell resolution, we identify networks of cortical neurons that project to LHb and then preferentially innervate different downstream brain sites, including the ventral tegmental area, median raphe nucleus, and locus coeruleus (LC). By using an intersectional chemogenetics approach, we show that inhibition of cortico-habenular neurons that project to LC, but not to other sites, blocks reinstatement of cocaine seeking. These findings highlight the remarkable complexity of descending cortical inputs to the habenula and identify a cortico-habenulo-hindbrain circuit that regulates cocaine seeking.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.