ArticleScience advances2021
TSC1 loss increases risk for tauopathy by inducing tau acetylation and preventing tau clearance via chaperone-mediated autophagy.
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Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed.
- Chaperone-mediated autophagy in physiological homeostasis, disease and ageing.Nature reviews. Molecular cell biology · 2026Review
- Autophagy-lysosomal pathway in neurodegeneration.Molecular neurodegeneration advances · 2026Review
- The lysosome and proteostatic stress at the intersection of pediatric neurological disorders and adult neurodegenerative diseases.Progress in neurobiology · 2025Review
- The Role of Sirt1 in Regulating Inflammatory Cytokines and Oxidative Stress in the Transition Mechanism from Depressive Disorder to Alzheimer's Disease.Molecular neurobiology · 2025Article
- Muscle peripheral circadian clock drives nocturnal protein degradation via raised Ror/Rev-erb balance and prevents premature sarcopenia.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Impaired degradation of PLCG1 by chaperone-mediated autophagy promotes cellular senescence and intervertebral disc degeneration.Autophagy · 2025Article
- Interaction between resveratrol and SIRT1: role in neurodegenerative diseases.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Multiple regulatory mechanisms, functions and therapeutic potential of chaperone-mediated autophagy.Theranostics · 2025Review
- Tau in neurodegenerative diseases: molecular mechanisms, biomarkers, and therapeutic strategies.Translational neurodegeneration · 2024Review
- Complicated Role of Post-translational Modification and Protease-Cleaved Fragments of Tau in Alzheimer's Disease and Other Tauopathies.Molecular neurobiology · 2024Review
- Near-infrared imaging for visualizing the synergistic relationship between autophagy and NFS1 protein during multidrug resistance using an ICT-TICT integrated platform.Chemical science · 2024Article
- The mTOR pathway geneseLife · 2024Article
- Second international symposium on the chaperone code, 2023.Cell stress & chaperones · 2024Article
- The mTOR pathway genesbioRxiv : the preprint server for biology · 2024Article
- Tau-targeting therapies for Alzheimer disease: current status and future directions.Nature reviews. Neurology · 2023Review
- Chaperone-mediated autophagy: Molecular mechanisms, biological functions, and diseases.MedComm · 2023Review
- Acetylation discriminates disease-specific tau deposition.Nature communications · 2023Article
- The Deficits of Insulin Signal in Alzheimer's Disease and the Mechanisms of Vanadium Compounds in Curing AD.Current issues in molecular biology · 2023Review
- Tau pathology in neurodegenerative disease: disease mechanisms and therapeutic avenues.The Journal of clinical investigation · 2023Review
- Mutations in α-synuclein, TDP-43 and tau prolong protein half-life through diminished degradation by lysosomal proteases.Molecular neurodegeneration · 2023Article
Corrections and comments
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Authors and funding
18 authors.
Carolina AlquezarUCSF Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA 94158, USA.ORCID 0000-0002-7602-3108
Kathleen M SchochDepartment of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Ethan G GeierDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94143, USA.
Eliana Marisa RamosDepartment of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
Aurora ScrivoInstitute for Aging Research, Albert Einstein College of Medicine, New York, NY 10461, USA.
Kathy H LiDepartment of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA 94158, USA.
Andrea R ArgouarchUCSF Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA 94158, USA.ORCID 0000-0002-0970-4894
Elisabeth E MlynarskiDepartment of Pathology and Laboratory Medicine, Penn Neurodegeneration Genomics Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-4238, USA.ORCID 0000-0002-6560-2876
Beth DombroskiDepartment of Pathology and Laboratory Medicine, Penn Neurodegeneration Genomics Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-4238, USA.ORCID 0000-0002-5334-1306
Michael DeTureDepartment of Neuroscience, The Mayo Clinic Florida, 4500 San Pablo Road, Jacksonville, FL 32224, USA.ORCID 0000-0002-4363-1262
Dennis W DicksonDepartment of Neuroscience, The Mayo Clinic Florida, 4500 San Pablo Road, Jacksonville, FL 32224, USA.ORCID 0000-0001-7189-7917
Jennifer S YokoyamaDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94143, USA.
Ana M CuervoInstitute for Aging Research, Albert Einstein College of Medicine, New York, NY 10461, USA.ORCID 0000-0002-0771-700X
Alma L BurlingameDepartment of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA 94158, USA.ORCID 0000-0002-8403-7307
Gerard D SchellenbergDepartment of Pathology and Laboratory Medicine, Penn Neurodegeneration Genomics Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-4238, USA.ORCID 0000-0003-1115-2475
Timothy M MillerDepartment of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-3424-5511
Bruce L MillerUCSF Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA 94158, USA.ORCID 0000-0002-2152-4220
Aimee W KaoUCSF Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA 94158, USA.ORCID 0000-0002-7686-7968
Funding
TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2MRole of Autophagy in T Cell Function and Immunosenescence (Project 3)P01AG031782 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI CUERVO, ANA MARIA · 2009 to 2024
$36.2MNIA NIH HHS P01 AG019724NIA NIH HHS P01 AG031782
Abstract
Age-associated neurodegenerative disorders demonstrating tau-laden intracellular inclusions are known as tauopathies. We previously linked a loss-of-function mutation in the
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.