ArticleeLife2021
Aversive stimuli bias corticothalamic responses to motivationally significant cues.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Modulatory mechanism of the paraventricular thalamus (PVT) under general anesthesia.Frontiers in pharmacology · 2026Review
- Divergent prefrontal cortex circuits regulate cued food seeking under distinct metabolic or emotional states.Nature communications · 2025Article
- Cathepsin B deficiency disrupts cortical development via PEG3, leading to depression-like behavior.Communications biology · 2025Article
- Article
- Functional properties of corticothalamic circuits targeting paraventricular thalamic neurons.Neuron · 2024Article
- Quantitative Fluorescence Analysis Reveals Dendrite-Specific Thalamocortical Plasticity in L5 Pyramidal Neurons during Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Can anxiety-like behavior and spatial memory predict the extremes of skilled walking performance in mice? An exploratory, preliminary study.Frontiers in behavioral neuroscience · 2023Article
- Functional Connectivity of the Human Paraventricular Thalamic Nucleus: Insights From High Field Functional MRI.Frontiers in integrative neuroscience · 2021Article
- Anterior Cingulate Cortex and the Control of Dynamic Behavior in Primates.Current biology : CB · 2020Review
- A ventrolateral medulla-midline thalamic circuit for hypoglycemic feeding.Nature communications · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Making predictions about future rewards or punishments is fundamental to adaptive behavior. These processes are influenced by prior experience. For example, prior exposure to aversive stimuli or stressors changes behavioral responses to negative- and positive-value predictive cues. Here, we demonstrate a role for medial prefrontal cortex (mPFC) neurons projecting to the paraventricular nucleus of the thalamus (PVT; mPFC→PVT) in this process. We found that a history of aversive stimuli negatively biased behavioral responses to motivationally relevant cues in mice and that this negative bias was associated with hyperactivity in mPFC→PVT neurons during exposure to those cues. Furthermore, artificially mimicking this hyperactive response with selective optogenetic excitation of the same pathway recapitulated the negative behavioral bias induced by aversive stimuli, whereas optogenetic inactivation of mPFC→PVT neurons prevented the development of the negative bias. Together, our results highlight how information flow within the mPFC→PVT circuit is critical for making predictions about motivationally-relevant outcomes as a function of prior experience.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.