Evidence map›Paper›PMID 34738867›Full record

ArticleBioengineered2021

Bone mesenchymal stem cells-derived miR-223-3p-containing exosomes ameliorate lipopolysaccharide-induced acute uterine injury via interacting with endothelial progenitor cells.

Yana Liu, Shihong Zhang, Zhiwei Xue, Xiaoxia Zhou, Lin Tong, Jiachen Liao, Huan Pan, Shu Zhou

Open access · goldAbstract read
In one paragraph

Article in Bioengineered, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

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  15. Exogenous HBioengineered · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Yana LiuDepartment of Obstetrics and Gynecology, Key Laboratory of Obstetric and Gynecologic and Pediatric Disease and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichaun, China.
Shihong ZhangDepartment of Obstetrics and Gynecology, Key Laboratory of Obstetric and Gynecologic and Pediatric Disease and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichaun, China.
Zhiwei XueDepartment of Obstetrics and Gynecology, Key Laboratory of Obstetric and Gynecologic and Pediatric Disease and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichaun, China.
Xiaoxia ZhouDepartment of Obstetrics and Gynecology, Key Laboratory of Obstetric and Gynecologic and Pediatric Disease and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichaun, China.
Lin TongDepartment of Obstetrics and Gynecology, Minerva Hospital for Women and Children, Chengdu, Sichuan, China.
Jiachen LiaoDepartment of Obstetrics and Gynecology, Key Laboratory of Obstetric and Gynecologic and Pediatric Disease and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichaun, China.
Huan PanDepartment of Obstetrics and Gynecology, Chengdu Second People's Hospital, Chengdu, Sichuan, China.
Shu ZhouDepartment of Obstetrics and Gynecology, Key Laboratory of Obstetric and Gynecologic and Pediatric Disease and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichaun, China.ORCID 0000-0002-6133-3007
Sichuan University · CNChengdu Second People's Hospital · CNChengdu Women's and Children's Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bone mesenchymal stem cells (BMSCs) have been used for the treatment of acute uterine injury (AUI)-induced intrauterine adhesion (IUA) via interacting with the endothelial progenitor cells (EPCs), and BMSCs-derived exosomes (BMSCs-exo) may be the key regulators for this process. However, the underlying mechanisms have not been studied. Based on the existed literatures, lipopolysaccharide (LPS) was used to induce AUI in mice models and EPCs to mimic the realistic pathogenesis of IUA

Indexed as

AnimalsApoptosisBase SequenceCell SurvivalCytokinesDisease Models, AnimalEndothelial Progenitor CellsExosomesFemaleGene SilencingHumansInflammation MediatorsLipopolysaccharidesMesenchymal Stem CellsMiceMice, Inbred BALB CCytokinesInflammation MediatorsLipopolysaccharidesMicroRNAsMIR223, humanProtective AgentsBone mesenchymal stem cellsendothelial progenitor cellsintrauterine adhesionmiR-223-3pNLRP3-mediated pyroptotic cell death

Identifiers

PMID34738867
PMCPMC8810142
OpenAlexW3210626977

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.