Evidence map›Paper›PMID 34738673›Full record

ArticleJournal of veterinary internal medicine2021

Serum feline pancreatic lipase immunoreactivity and trypsin-like immunoreactivity concentrations in cats with experimentally induced chronic kidney disease.

Panagiotis G Xenoulis, Katerina T Moraiti, Delmar R Finco, Jan S Suchodolski, Jörg M Steiner

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Article in Journal of veterinary internal medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Panagiotis G XenoulisTexas A&M University, College of Veterinary Medicine and Biomedical Sciences, Gastrointestinal Laboratory, College Station, Texas, USA.ORCID https://orcid.org/0000-0002-9508-0271
Katerina T MoraitiDepartment of Medicine, University of Thessaly, Karditsa, Greece.
Delmar R FincoDepartment of Physiology and Pharmacology, University of Georgia, Athens, Georgia, USA.
Jan S SuchodolskiSmall Animal Sciences, GI Laboratory, College Station, Texas, USA.ORCID https://orcid.org/0000-0002-2176-6932
Jörg M SteinerVSCS, GI Lab, College Station, Texas, USA.ORCID https://orcid.org/0000-0003-3336-2086

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSerum feline pancreatic lipase immunoreactivity (fPLI) and trypsin-like immunoreactivity (fTLI) concentrations are commonly used in cats for the evaluation of pancreatic disease. The effect of kidney disease on these tests in cats are unknown.

objectiveTo investigate the effect of experimentally induced chronic kidney disease (CKD) on serum fPLI and fTLI concentrations. ANIMALS: Surplus serum samples from 20 cats with CKD experimentally induced for an unrelated project and a group of healthy control cats.

methodsSerum fTLI and fPLI concentrations were compared between groups.

resultsMean (±SD) serum fTLI concentrations in 20 cats with CKD (117.8 ± 63.6 μg/L) were significantly higher than those in healthy cats (n = 32; 46.9 ± 17.5 μg/L; P < .0001). Serum fTLI concentrations in cats with CKD were above the upper limit of the reference interval in 13 of 20 cats (65%). Serum fPLI concentrations were not significantly different between cats with induced CKD (n = 18; 8.6 μg/L; range, 5.4-9.9 μg/L) and healthy cats (n = 41; 7.4 μg/L; range, 5.0-15.2 μg/L; P = .12). All cats with experimentally induced CKD had serum fPLI concentrations within the reference interval. CONCLUSIONS AND CLINICAL IMPORTANCE: Decreased renal function has a clinically relevant impact on serum fTLI concentrations and potentially could interfere with a diagnosis of exocrine pancreatic insufficiency (EPI). Serum fPLI concentration was not affected by experimentally induced CKD and thus serum fPLI may be used for the diagnosis of pancreatitis in cats with kidney disease. Additional studies are needed to verify these results in cats with naturally occurring CKD.

Indexed as

Cat DiseasesPancreatitisRenal Insufficiency, ChronicAnimalsCatsLipasePancreasTrypsinLipaseTrypsinazotemiagastroenterologypancreaspancreatic diseasepancreatic insufficiencypancreatic lipasepancreatitisrenal diseaserenal/urinary tract

Identifiers

PMID34738673
PMCPMC8692220

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.