Evidence map›Paper›PMID 34738567›Full record

SynthesisActa bio-medica : Atenei Parmensis2021

Pleural effusion aetiology, presentation, treatment and outcome in haematological diseases: a review.

Alberto Fantin, Nadia Castaldo, Paolo Vailati, Giuseppe Morana, Daniele Orso, Luigi Vetrugno, Vincenzo Patruno

Open access · greenAbstract readSystematic Review
In one paragraph

Synthesis in Acta bio-medica : Atenei Parmensis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
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  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Alberto FantinDepartment of Pulmonology, Azienda Sanitaria Universitaria Integrata di Udine, Udine, Italy. af@albertofantin.com.
Nadia CastaldoDepartment of Pulmonology, Azienda Sanitaria Universitaria Integrata di Udine, Udine, Italy; Department of Infectious diseases, Azienda Sanitaria Universitaria Integrata di Udine, Udine, Italy;. nadiacastaldo.nc@gmail.com.
Paolo VailatiDepartment of Pulmonology, Azienda Sanitaria Universitaria Integrata di Udine, Udine, Italy. paolo.vailati@asufc.sanita.fvg.it.
Giuseppe MoranaDepartment of Pulmonology, Azienda Sanitaria Universitaria Integrata di Udine, Udine, Italy. giuseppe.morana@asufc.sanita.fvg.it.
Daniele OrsoDepartment of Medicine, University of Udine, via Colugna n° 50, 33100, Udine, Italy. . sd7782.do@gmail.com.
Luigi VetrugnoDepartment of Medicine, University of Udine, via Colugna n° 50, 33100, Udine, Italy; Anesthesia and Intensive Care Medicine Department, ASUFC University-Hospital of Central Friuli, ASUFC, P.le S. Maria della Misericordia n° 15, 33100, Udine, Italy. luigi.vetrugno@asufc.sanita.fvg.it.
Vincenzo PatrunoDepartment of Pulmonology, Azienda Sanitaria Universitaria Integrata di Udine, Udine, Italy. vincenzo.patruno@asufc.sanita.fvg.it.
Ospedale Santa Maria della Misericordia di Udine · ITUniversity of Udine · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimPleural effusions (PE) can complicate the course of hematologic disorders (HD) and may arise in the form of malignant PE or as a consequence of non-neoplastic complications. While a certain amount of data has been published regarding infectious and iatrogenic HD-associated PE (HPE), no comprehensive review regarding the other types of HPE has ever been conducted. To address this issue, we performed a systematic review of the literature regarding HPE, focusing on the clinical and chemical characteristics of PE, therapeutic approaches and ì outcomes at the one-year follow-up.

methodsWe conducted our review according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.

resultsOverall, 283 manuscripts and 1216 cases were included. In summary, PE frequently signals an underlying HD, especially Hodgkin's lymphoma and IgG4-related disease; it mainly consists of exudate, although chylothorax is diagnosed in some cases. Although cytological examination has a discrete diagnostic yield, it is generally insufficient to render a definitive diagnosis; pleural biopsy remains an important diagnostic means in such cases. Invasive diagnostic procedures are not frequently performed because of an increased risk of haemorrhagic complications. The majority of PE are resolved by means of systemic therapy. When local treatments are attempted, the most frequently adopted procedures are evacuative thoracentesis and indwelling chest tube placement Conclusions: This review highlights the need for well-designed prospective studies comparing diagnostic means and therapeutic interventions for HPE to increase the quality of available data.  (www.actabiomedica.it).

Indexed as

Hematologic DiseasesPleural EffusionExudates and TransudatesHumansProspective StudiesTreatment Outcome

Identifiers

PMID34738567
PMCPMC8689299
OpenAlexW3210866924

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.