Evidence map›Paper›PMID 34738205›Full record

ArticleInternational ophthalmology2022

Early corneal and optic nerve changes in a paediatric population affected by obstructive sleep apnea syndrome.

Erika Bonacci, Adriano Fasolo, Marco Zaffanello, Tommaso Merz, Giacomo Brocoli, Angelo Pietrobelli, Maria Clemente, Alessandra De Gregorio, Rosa Longo, Francesca Bosello and 2 more

Abstract read
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In one paragraph

Article in International ophthalmology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Obesity, body fat distribution and eye diseases.Eating and weight disorders : EWD · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Erika BonacciEye Clinic, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Pz.Le LA Scuro 10, 37100, Verona, VR, Italy.
Adriano FasoloEye Clinic, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Pz.Le LA Scuro 10, 37100, Verona, VR, Italy.
Marco ZaffanelloPediatric Division, Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, Piazzale Stefani 1, 37126, Verona, VR, Italy.
Tommaso MerzEye Clinic, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Pz.Le LA Scuro 10, 37100, Verona, VR, Italy.
Giacomo BrocoliEye Clinic, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Pz.Le LA Scuro 10, 37100, Verona, VR, Italy.
Angelo PietrobelliPediatric Division, Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, Piazzale Stefani 1, 37126, Verona, VR, Italy.
Maria ClementePediatric Division, Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, Piazzale Stefani 1, 37126, Verona, VR, Italy.
Alessandra De GregorioOphthalmic Unit, San Bassiano Hospital, Via dei Lotti, 40, 36061, Bassano del Grappa, VI, Italy.
Rosa LongoEye Clinic, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Pz.Le LA Scuro 10, 37100, Verona, VR, Italy.
Francesca BoselloEye Clinic, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Pz.Le LA Scuro 10, 37100, Verona, VR, Italy. francesca.bosello87@gmail.com.ORCID http://orcid.org/0000-0003-0082-2197
Giorgio MarchiniEye Clinic, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Pz.Le LA Scuro 10, 37100, Verona, VR, Italy.
Emilio PedrottiEye Clinic, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Pz.Le LA Scuro 10, 37100, Verona, VR, Italy.
University of Verona · ITOspedale San Bassiano · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe relation between OSAS and eye diseases is well known in adults, while very few and contradictory data can be found regarding paediatric ages. The aim of this study is to explore the early corneal, macular and optic nerve changes in paediatric patients with OSAS.

methodsProspective study that enrolled children aged ≥ 4 years referred to the Paediatric Pneumology Clinic in Verona for suspected obstructive sleep apnoea syndrome (OSAS) and investigated with the overnight respiratory polygraphy. Patients with apnoea-hypopnea index (AHI) > 1 were classified as OSAS, while those with AHI < 1 were classified non-OSAS. All patients underwent comprehensive eye examination including slit lamp, refraction, intraocular pression (Goldman applanation tonometry), corneal tomography (corneal astigmatism, corneal keratometry at the apex, surface asymmetry index, central corneal thickness and thinnest corneal thickness) and optical coherence tomography (central macular thickness, macular volume and retinal nerve fibre layer).

resultsSeventy-two children were enrolled in the study. The overall prevalence of OSAS was 48.6%. Statistically significant differences were found between OSAS and non-OSAS group for corneal asymmetry (0.9 ± 0.5 and 0.6 ± 0.3, respectively; p = 0.02), thinnest corneal thickness (551.8 ± 33.9 and 563.7 ± 32.5; p = 0.04), average retinal nerve fibre layer (102.8 ± 10.5 µm and 98.1 ± 12.3 µm; p = 0.012) and in nasal quadrant (76.2 ± 15.4 µm and 66.5 ± 12.6 µm; p = 0.0002).

conclusionsA comprehensive eye examination with corneal and optic nerve imaging showed early corneal and optic nerve changes in children newly diagnosed with OSAS. These could be prelude of the known ocular manifestations associated with OSAS in adult patients.

Indexed as

Nerve FibersSleep Apnea, ObstructiveAdultChildHumansOptic NerveProspective StudiesRetinal Ganglion CellsTomography, Optical CoherenceKeratoconusObstructive sleep apnoea syndromeOSASPaediatric ophthalmologyRNFLSleep respiratory disorders

Identifiers

PMID34738205
OpenAlexW3167956194

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.