Evidence map›Paper›PMID 34738033›Full record

ArticleAnimal nutrition (Zhongguo xu mu shou yi xue hui)2021

The in ovo injection of methionine improves intestinal cell proliferation and differentiation in chick embryos by activating the JAK2/STAT3 signaling pathway.

Meng-Jie Chen, Jia-Yi Zhou, Yi-Jun Chen, Xiu-Qi Wang, Hui-Chao Yan, Chun-Qi Gao

Open access · goldAbstract read
In one paragraph

Article in Animal nutrition (Zhongguo xu mu shou yi xue hui), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 29 citations in OpenAlex.

  1. Maternal methionine supplementation regulates skeletal muscle development through NAnimal nutrition (Zhongguo xu mu shou yi xue hui) · 2026
    Article
  2. In ovo injection of vitamin DPoultry science · 2026
    Article
  3. Maternal curcumin supplementation alleviates intestinal inflammation ofAnimal nutrition (Zhongguo xu mu shou yi xue hui) · 2026
    Article
  4. Article
  5. Article
  6. Chicken Primordial Germ Cells Do Not Proliferate in Insulin-Lacking Media.International journal of molecular sciences · 2025
    Article
  7. Article
  8. Review
  9. Article
  10. Embryonic methionine triggers post-natal developmental programming in Japanese quail.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2024
    Article
  11. Article
  12. Article
  13. Frontiers in veterinary science · 2023
    Article
  14. Effects ofFrontiers in veterinary science · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Meng-Jie ChenCollege of Animal Science, South China Agricultural University/Guangdong Provincial Key Laboratory of Animal Nutrition Control, Guangzhou, 510642, China.
Jia-Yi ZhouCollege of Animal Science, South China Agricultural University/Guangdong Provincial Key Laboratory of Animal Nutrition Control, Guangzhou, 510642, China.
Yi-Jun ChenCollege of Animal Science, South China Agricultural University/Guangdong Provincial Key Laboratory of Animal Nutrition Control, Guangzhou, 510642, China.
Xiu-Qi WangCollege of Animal Science, South China Agricultural University/Guangdong Provincial Key Laboratory of Animal Nutrition Control, Guangzhou, 510642, China.
Hui-Chao YanCollege of Animal Science, South China Agricultural University/Guangdong Provincial Key Laboratory of Animal Nutrition Control, Guangzhou, 510642, China.
Chun-Qi GaoCollege of Animal Science, South China Agricultural University/Guangdong Provincial Key Laboratory of Animal Nutrition Control, Guangzhou, 510642, China.
South China Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The intestinal health of chick embryos is vital for their life-long growth, and exogenous nutrition intervention may provide sufficient nutrition for embryonic development. In the present study, we investigated the effect of in ovo injection of L-methionine (L-Met) on the intestinal structure and barrier function of chick embryos. There were 4 groups of treatments: the control (CON) group injected with phosphate-buffered saline (PBS) and the other 3 groups injected with 5, 10, and 20 mg L-Met/egg, respectively. The injection was performed on embryonic day 9 (E9), and intestinal samples were collected on the day of hatching for analysis. The results showed that, compared with the CON group, the groups administered an in ovo injection of L-Met increased relative weights of the duodenum, jejunum, and ileum (

Indexed as

ChickIn ovo injectionIntestineJAK2/STAT3L-methionine

Identifiers

PMID34738033
PMCPMC8536505
OpenAlexW3192794394

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.