Evidence map›Paper›PMID 34737980›Full record

ReviewFrontiers in cellular and infection microbiology2021

PRD-Containing Virulence Regulators (PCVRs) in Pathogenic Bacteria.

Joseph S Rom, Meaghan T Hart, Kevin S McIver

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in cellular and infection microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

  1. Paradigm shift formBio · 2026
    Article
  2. Article
  3. Article
  4. Environmental Regulation of Toxin Production inbioRxiv : the preprint server for biology · 2025
    Article
  5. Review
  6. TheInfection and immunity · 2024
    Article
  7. The Impact ofPathogens (Basel, Switzerland) · 2024
    Review
  8. Review
  9. Article
  10. Article
  11. Expression of the Bacillus thuringiensisMicrobiology spectrum · 2022
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Joseph S RomCell Biology & Molecular Genetics, University of Maryland, College Park, MD, United States.
Meaghan T HartCell Biology & Molecular Genetics, University of Maryland, College Park, MD, United States.
Kevin S McIverCell Biology & Molecular Genetics, University of Maryland, College Park, MD, United States.
University of Maryland, College Park · US

Funding

PRD-Containing Virulence Regulators of Pathogenic StreptococciR01AI047928 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI MCIVER, KEVIN S. · 2001 to 2023
$6.5M
Training in Host-pathogens interactionsT32AI089621 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI LEE, VINCENT T, MCIVER, KEVIN S. · 2010 to 2025
$2.1M
NIAID NIH HHS R01 AI047928NIAID NIH HHS T32 AI089621
6 · The paper itself

Abstract

Bacterial pathogens rely on a complex network of regulatory proteins to adapt to hostile and nutrient-limiting host environments. The phosphoenolpyruvate phosphotransferase system (PTS) is a conserved pathway in bacteria that couples transport of sugars with phosphorylation to monitor host carbohydrate availability. A family of structurally homologous PTS-regulatory-domain-containing virulence regulators (PCVRs) has been recognized in divergent bacterial pathogens, including

Indexed as

Bacillus anthracisGene Expression Regulation, BacterialBacterial ProteinsStreptococcus pyogenesVirulenceBacterial ProteinsAtxAMafRMgaMgaSpnnucleoid associated proteinPCVRPTS phosphorylation

Identifiers

PMID34737980
PMCPMC8560693
OpenAlexW3207715870

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.