Evidence map›Paper›PMID 34737962›Full record

ArticleFrontiers in oncology2021

A Germline Variant at 8q24 Contributes to the Serum p2PSA Level in a Chinese Prostate Biopsy Cohort.

Xiaoling Lin, Yishuo Wu, Fang Liu, Rong Na, Da Huang, Danfeng Xu, Jian Gong, Yao Zhu, Bo Dai, Dingwei Ye and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 1 country.

Xiaoling LinDepartment of Urology, Huashan Hospital, Fudan University, Shanghai, China.
Yishuo WuDepartment of Urology, Huashan Hospital, Fudan University, Shanghai, China.
Fang LiuDepartment of Urology, Huashan Hospital, Fudan University, Shanghai, China.
Rong NaDepartment of Urology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Da HuangDepartment of Urology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Danfeng XuDepartment of Urology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jian GongDepartment of Urology, Huashan Hospital, Fudan University, Shanghai, China.
Yao ZhuDepartment of Urology, Shanghai Cancer Center, Fudan University, Shanghai, China.
Bo DaiDepartment of Urology, Shanghai Cancer Center, Fudan University, Shanghai, China.
Dingwei YeDepartment of Urology, Shanghai Cancer Center, Fudan University, Shanghai, China.
Hongjie YuState Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China.
Haowen JiangDepartment of Urology, Huashan Hospital, Fudan University, Shanghai, China.
Zujun FangDepartment of Urology, Huashan Hospital, Fudan University, Shanghai, China.
Jie ZhengDepartment of Urology, Huashan Hospital, Fudan University, Shanghai, China.
Qiang DingDepartment of Urology, Huashan Hospital, Fudan University, Shanghai, China.
Huashan Hospital · CNFudan University · CNFudan University Shanghai Cancer Center · CNShanghai Jiao Tong University · CNRuijin Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe clinical performance of [-2]proPSA (p2PSA) and its derivatives in predicting the presence and aggressiveness of prostate cancer (PCa) has been well evaluated in prostate biopsy patients. However, no study has been performed to evaluate the common genetic determinants that affect serum level of p2PSA. MATERIALS AND

methodsHere, we performed a two-stage genome-wide association study (GWAS) on the p2PSA level in Chinese men who underwent a transperineal ultrasound-guided prostate biopsy at Huashan Hospital, Shanghai Cancer Center, and Ruijin Hospital in Shanghai, China. Germline variants significantly associated with the p2PSA level in the first stage (

resultsA novel non-synonymous SNP, rs72725879, in region 8q24.21 of the

conclusionsOur study shows that the genetic variants in the 8q24.21 region are associated with the serum level of p2PSA in a large-scale Chinese population. By taking inherited variations between individuals into account, the findings of these genetic variants may help improve the performance of p2PSA in predicting prostate cancer.

Indexed as

Chinesegenome-wide association studyp2PSApolymorphismprostate cancer

Identifiers

PMID34737962
PMCPMC8560794
OpenAlexW3206743115

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.