Evidence map›Paper›PMID 34737959›Full record

ReviewFrontiers in oncology2021

Executive Summary of Clinical and Technical Guidelines for Esophageal Cancer Proton Beam Therapy From the Particle Therapy Co-Operative Group Thoracic and Gastrointestinal Subcommittees.

Michael D Chuong, Christopher L Hallemeier, Heng Li, Xiaorong Ronald Zhu, Xiaodong Zhang, Erik J Tryggestad, Jen Yu, Ming Yang, J Isabelle Choi, Minglei Kang and 11 more

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Towards proton therapy guidelines for radiation therapists and dosimetrists: A scoping review.Technical innovations & patient support in radiation oncology · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 9 institutions in 2 countries.

Michael D ChuongDepartment of Radiation Oncology, Miami Cancer Institute, Miami, FL, United States.
Christopher L HallemeierDepartment of Radiation Oncology, Mayo Clinic, Rochester, MN, United States.
Heng LiDepartment of Radiation Oncology, Johns Hopkins University, Baltimore, MD, United States.
Xiaorong Ronald ZhuDepartment of Radiation Oncology, MD Anderson Cancer Center, Houston, TX, United States.
Xiaodong ZhangDepartment of Radiation Oncology, MD Anderson Cancer Center, Houston, TX, United States.
Erik J TryggestadDepartment of Radiation Oncology, Mayo Clinic, Rochester, MN, United States.
Jen YuDepartment of Radiation Oncology, Miami Cancer Institute, Miami, FL, United States.
Ming YangDepartment of Radiation Oncology, MD Anderson Cancer Center, Houston, TX, United States.
J Isabelle ChoiDepartment of Radiation Oncology, New York Proton Center, New York, NY, United States.
Minglei KangDepartment of Radiation Oncology, New York Proton Center, New York, NY, United States.
Wei LiuDepartment of Radiation Oncology, Mayo Clinic, Scottsdale, AZ, United States.
Antje KnopfDepartment of Radiation Oncology, University of Groningen, Groningen, Netherlands.
Arturs MeijersDepartment of Radiation Oncology, University of Groningen, Groningen, Netherlands.
Jason K MolitorisDepartment of Radiation Oncology, University of Maryland, Baltimore, Baltimore, MD, United States.
Smith ApisarnthanaraxDepartment of Radiation Oncology, University of Washington, Seattle, WA, United States.
Huan GiapDepartment of Radiation Oncology, University of Miami, Miami, FL, United States.
Bradford S HoppeDepartment of Radiation Oncology, Mayo Clinic, Jacksonville, FL, United States.
Percy LeeDepartment of Radiation Oncology, MD Anderson Cancer Center, Houston, TX, United States.
Joe Y ChangDepartment of Radiation Oncology, MD Anderson Cancer Center, Houston, TX, United States.
Charles B SimoneDepartment of Radiation Oncology, New York Proton Center, New York, NY, United States.
Steven H LinDepartment of Radiation Oncology, MD Anderson Cancer Center, Houston, TX, United States.
The University of Texas MD Anderson Cancer Center · USMayo Clinic in Arizona · USNew York Proton Center · USUniversity of Groningen · NLJohns Hopkins University · USMayo Clinic in Florida · USUniversity of Maryland, Baltimore · USUniversity of Miami · USUniversity of Washington · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Radiation therapy (RT) is an integral component of potentially curative management of esophageal cancer (EC). However, RT can cause significant acute and late morbidity due to excess radiation exposure to nearby critical organs, especially the heart and lungs. Sparing these organs from both low and high radiation dose has been demonstrated to achieve clinically meaningful reductions in toxicity and may improve long-term survival. Accruing dosimetry and clinical evidence support the consideration of proton beam therapy (PBT) for the management of EC. There are critical treatment planning and delivery uncertainties that should be considered when treating EC with PBT, especially as there may be substantial motion-related interplay effects. The Particle Therapy Co-operative Group Thoracic and Gastrointestinal Subcommittees jointly developed guidelines regarding patient selection, treatment planning, clinical trials, and future directions of PBT for EC.

Indexed as

chemoradiationesophageal cancerpassive scatter protonpencil beam scanningproton beam therapy (PBT)

Identifiers

PMID34737959
PMCPMC8560961
OpenAlexW3207502778

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.