Evidence map›Paper›PMID 34737948›Full record

ArticleFrontiers in oncology2021

Proteomics-Based Identification of Candidate Exosomal Glycoprotein Biomarkers and Their Value for Diagnosing Colorectal Cancer.

Zujun Sun, Shurong Ji, Junlu Wu, Jiale Tian, Wenqiang Quan, Anquan Shang, Ping Ji, Weidong Xiao, Ding Liu, Xuan Wang and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.

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  5. Extracellular vesicles in colorectal cancer.Annals of coloproctology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Zujun SunDepartment of Clinical Medicine, Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Shurong JiDepartment of General Surgery, Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Junlu WuDepartment of Clinical Medicine, Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Jiale TianDepartment of Clinical Medicine, Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Wenqiang QuanDepartment of Clinical Medicine, Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Anquan ShangDepartment of Clinical Medicine, Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Ping JiDepartment of Clinical Medicine, Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Weidong XiaoHerman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, United States.
Ding LiuDepartment of Chemistry, Georgia State University, Atlanta, GA, United States.
Xuan WangDepartment of Pharmacy, Shanghai Putuo People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Dong LiDepartment of Clinical Medicine, Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Tongji University · CNTongji Hospital · CNGeorgia State University · USIndiana University School of Medicine

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Early diagnosis and treatment of colorectal cancer (CRC) significantly improves the survival rate and quality of life. Here we screened for differences in glycoproteins associated with tumor-derived exosomes and validated their clinical value to serve as liquid biopsy biomarkers to diagnosed early CRC. Exosomes were extracted from paracancerous tissues, cancer tissues, and plasma. LC-MS/MS proteomic and glycoproteomics analyses were performed using an LTQ-Orbitrap Elite mass spectrometer. The differences in glycoproteins associated with exosomes of paracancerous tissues and cancer tissue were determined, and their levels in plasma exosomes were determined. Statistical analysis was performed to evaluate the diagnostic efficacy of exosome-associated glycoproteins for CRC. We found that the levels of fibrinogen beta chain (FGB) and beta-2-glycoprotein 1 (β2-GP1) in the exosome of CRC tissue were significantly higher compared with those of paracancerous tissues exosome. The areas under the receiver operating characteristic (ROC) curves of plasma exosomal FGB and β2-GP1 as biomarkers for CRC were 0.871 (95% CI = 0.786-0.914) and 0.834 (95% CI = 0.734-0.901), respectively, compared with those of the concentrations of carcinoembryonic antigen concentration [0.723 (95% CI = 0.679-0.853)] and carbohydrate antigen19-9 concentration [0.614 (95% CI = 0.543-0.715)]. Comprehensive proteomics analyses of plasma exosomal biomarkers in CRC identified biomarkers with significant diagnostic efficacy for early CRC, which can be measured using relatively non-invasive techniques.

Indexed as

beta-2-glycoproteincolorectal cancerexosomefibrinogen beta chainreceiver operating characteristic

Identifiers

PMID34737948
PMCPMC8560707
OpenAlexW3207910652

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.