Evidence map›Paper›PMID 34737675›Full record

ArticleCanada communicable disease report = Releve des maladies transmissibles au Canada2021

Influenza vaccine during the 2019-2020 season and COVID-19 risk: A case-control study in Québec.

Jacques Pépin, Philippe De Wals, Annie-Claude Labbé, Alex Carignan, Marie-Elise Parent, Jennifer Yu, Louis Valiquette, Marie-Claude Rousseau

Open access · diamondAbstract read
In one paragraph

Article in Canada communicable disease report = Releve des maladies transmissibles au Canada, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 1 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Jacques PépinUniversité de Sherbrooke, Sherbrooke, QC.
Philippe De WalsUniversité Laval, Québec, QC.
Annie-Claude LabbéCIUSSS de l'Est-de-l'Ile-de-Montréal, Montréal, QC.
Alex CarignanUniversité de Sherbrooke, Sherbrooke, QC.
Marie-Elise ParentInstitut national de la recherche scientifique, Laval, QC.
Jennifer YuInstitut national de la recherche scientifique, Laval, QC.
Louis ValiquetteUniversité de Sherbrooke, Sherbrooke, QC.
Marie-Claude RousseauInstitut national de la recherche scientifique, Laval, QC.
Institut National de la Recherche Scientifique · CAUniversité de Sherbrooke · CAUniversité de Montréal · CAUniversité Laval · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe carried out a case-control study that examined whether receipt of the inactivated influenza vaccine during the 2019-2020 season impacted on the risk of coronavirus disease 2019 (COVID-19), as there was a concern that the vaccine could be detrimental through viral interference.

methodsA total of 920 cases with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (diagnosed between March and October 2020) and 2,123 uninfected controls were recruited from those who were born in Québec between 1956 and 1976 and who had received diagnostic services at two hospitals (Montréal and Sherbrooke, Québec). After obtaining consent, a questionnaire was administered by phone. Data were analyzed by logistic regression.

resultsAmong healthcare workers, inactivated influenza vaccine received during the previous influenza season was not associated with increased COVID-19 risk (AOR: 0.99, 95% CI: 0.69-1.41). Among participants who were not healthcare workers, influenza vaccination was associated with lower odds of COVID-19 (AOR: 0.73, 95% CI 0.56-0.96).

conclusionWe found no evidence that seasonal influenza vaccine increased the risk of developing COVID-19.

Indexed as

COVID-19influenza vaccineSARS-CoV-2seasonal influenza

Identifiers

PMID34737675
PMCPMC8525604
OpenAlexW3207967017

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.